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Nontuberculous mycobacteria (NTM) are emerging as notable causative agents of opportunistic infections. To examine clinical significance, species distribution, and temporal trends of NTM in Denmark, we performed a nationwide register-based study of all unique persons with NTM isolated in the country during 1991-2022. We categorized patients as having definite disease, possible disease, or isolation by using a previously validated method.
View Article and Find Full Text PDFClinical spectrum and relevance of Mycobacterium malmoense: Systematic review and meta-analysis of 859 patients.
J Infect
August 2024
Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), TTU-TB, Borstel, Germany; Respiratory Medicine and International Health, University of Lübeck, Lübeck, Germany; Baylor College of Medicine and Texas Children´s Hospital, Houston, TX, USA.
Article Synopsis
- The study focuses on the clinical significance of Mycobacterium malmoense infections, especially in pulmonary specimens, noting that this pathogen is more relevant than other non-tuberculous mycobacteria.
- Through a systematic review and meta-analysis of existing literature, the researchers analyzed data from 188 individual patients and pooled data from 671 patients, finding that pulmonary infections were the most common, but a significant number also had extra-pulmonary or disseminated disease.
- The results suggest that a high percentage (68%) of patients had clinically relevant disease, and treatment regimens that include macrolides and rifamycins significantly improved survival rates in these patients.
Pulmonary Infection Caused by Mycobacterium malmoense and the Difficulties in Distinguishing It From the Pulmonary Mycobacterium tuberculosis Infection.
Cureus
April 2024
Department of Respiratory Medicine, Naga Municipal Hospital, Kinokawa, JPN.
is a rare species of non-tuberculosis mycobacteria detected in Japan that causes pulmonary infection and cervical lymphadenitis. Here, we report a case of pulmonary infection caused by , which was difficult to distinguish from (Mtb) infection. A 64-year-old Japanese woman with a history of pulmonarytuberculosis had bloody phlegm, a cough, and discomfort in her chest.
View Article and Find Full Text PDFMycobacterium malmoense wrist septic arthritis.
Enferm Infecc Microbiol Clin (Engl Ed)
April 2024
Servicio de Reumatología, Hospital Universitario de Ourense, Orense, Spain.
Treatment of the Less Common Nontuberculous Mycobacterial Pulmonary Disease.
Clin Chest Med
December 2023
Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Respirology, University Health Network, Toronto, Ontario, Canada. Electronic address:
Nontuberculous mycobacterial pulmonary disease caused by the less common nontuberculous mycobacteria have distinct features depending on the species. Diagnostic evaluation follows the established criteria for all nontuberculous mycobacteria, but with certain qualifications given species-specific and regional differences in pathogenicity. Clinicians should first institute nonpharmacologic management and evaluate clinical, radiologic, and microbiologic factors in the decision regarding antimycobacterial therapy.
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