Caecal malakoplakia: a rare mimic of malignancy.

BMJ Case Rep

Radiology, North Bristol NHS Trust, Bristol, UK.

Published: January 2024

Malakoplakia is a rare granulomatous disease. Its aetiology is unclear but possible theories include infection with microorganisms (especially ), immunosuppression and impaired lysosomal function. It has been commonly documented to affect the genitourinary tract but can affect any organ, with the gastrointestinal system being the next most affected. We present a woman in her 70s, with a 2-week history of right-sided abdominal pain, 13 years following her renal transplant. She was admitted for treatment of an bacteraemia. CT scan had shown a caecal pole mass, highly suspicious for malignancy. It was surgically resected, and histology revealed findings of malakoplakia within the colon. Surgical intervention was combined with a prolonged course of antibiotics for successful treatment. We highlight the ability of malakoplakia to mimic malignancy and should be considered in the differentials in the context of an immunosuppressed patient with radiological findings of a colonic mass.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826489PMC
http://dx.doi.org/10.1136/bcr-2023-257130DOI Listing

Publication Analysis

Top Keywords

malakoplakia rare
8
mimic malignancy
8
caecal malakoplakia
4
rare mimic
4
malignancy malakoplakia
4
rare granulomatous
4
granulomatous disease
4
disease aetiology
4
aetiology unclear
4
unclear theories
4

Similar Publications

In the present case, a 66-year-old woman presented to the Specialty Hospital (Amman, Jordan) with recurrent post-menopausal bleeding. A pelvic ultrasound scan showed an abnormal endometrial thickness of 8 mm and no adnexal masses. An endometrial biopsy revealed abundant foamy histiocyte infiltration features suggestive of xanthogranulomatous endometritis.

View Article and Find Full Text PDF

Unlabelled: Malakoplakia is a rare granulomatous condition that occurs due to defective lysosomal digestion during phagocytosis and can mimic inflammatory bowel disease (IBD) or malignancies, particularly in immunosuppressed patients. We report the case of a 62-year-old male with IgG4-related orbitopathy, who developed persistent diarrhoea and colonic lesions 6 weeks after receiving rituximab therapy for nephrotic syndrome secondary to membranoproliferative glomerulonephritis. Colonoscopy revealed pancolitis with mucosal granularity, loss of vascular pattern, and small nodules, raising initial suspicion for IBD.

View Article and Find Full Text PDF

Recurrent bladder malakoplakia: A rare bladder lesion mimicking malignancy.

Bladder (San Franc)

November 2024

Department of Pathology and Laboratory Medicine, Brantford General Hospital, Brantford, Ontario N3R 1G9, Canada.

Background: Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract with the urinary bladder being the most frequently affected site. It is characterized by histiocytes containing distinct basophilic calcified inclusions called Michaelis-Gutmann bodies. It is believed to result from abnormally functioning macrophages, with inclusions representing calcifications around incompletely digested bacteria.

View Article and Find Full Text PDF

Pulmonary malakoplakia due to Prescottella (Rhodococcus) soli in a renal transplant recipient: First reported case.

Eur J Microbiol Immunol (Bp)

December 2024

1Department of Microbiology, NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia.

Prescottella (Rhodococcus) soli is a soil-dwelling organism not previously thought to be pathogenic in humans. We discuss the case of a 78-year-old male renal transplant recipient presenting with respiratory symptoms and multiple pulmonary nodules, found to be pulmonary malakoplakia secondary to infection with Prescottella (Rhodococcus) soli. Treatment was commenced with vancomycin, meropenem and azithromycin for an induction period of two weeks and continued with indefinite oral moxifloxacin and azithromycin with significant clinical improvement.

View Article and Find Full Text PDF

A rare case of prostatic malakoplakia with multidrug-resistant Escherichia coli: a case report.

BMC Infect Dis

October 2024

Department of Pathology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Prostatic malakoplakia is an uncommon chronic inflammatory disorder, tumor-like but non-cancerous, the diagnosis of which pivots crucially on the identification of characteristic Michaelis-Gutmann bodies within the pathological tissue. We hereby present an inaugural case report of prostatic malakoplakia concurrent with sepsis caused by multidrug-resistant Escherichia coli, verified through blood culture and metagenomic next-generation sequencing (mNGS). The pathogenesis might be associated with infections by Escherichia coli, immune system irregularities, or lysosomal dysfunction.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!