AI Article Synopsis
- Understanding exercise response variation is crucial for creating personalized exercise prescriptions, influenced by both extrinsic factors (like timing, sleep, and diet) and intrinsic factors (such as age, sex, and genetics).
- Molecular elements like genomic, proteomic, and metabolomic factors play a significant role in how individuals respond to exercise, affecting their health outcomes.
- The MoTrPAC initiative seeks to address the gaps in knowledge about exercise response, but more research is needed to develop effective, individualized recommendations for diverse populations.
Article Abstract
Understanding the factors that contribute to exercise response variation is the first step in achieving the goal of developing personalized exercise prescriptions. This review discusses the key molecular and other mechanistic factors, both extrinsic and intrinsic, that influence exercise responses and health outcomes. Extrinsic characteristics include the timing and dose of exercise, circadian rhythms, sleep habits, dietary interactions, and medication use, whereas intrinsic factors such as sex, age, hormonal status, race/ethnicity, and genetics are also integral. The molecular transducers of exercise (i.e., genomic/epigenomic, proteomic/post-translational, transcriptomic, metabolic/metabolomic, and lipidomic elements) are considered with respect to variability in physiological and health outcomes. Finally, this review highlights the current challenges that impede our ability to develop effective personalized exercise prescriptions. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to fill significant gaps in the understanding of exercise response variability, yet further investigations are needed to address additional health outcomes across all populations.
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| http://dx.doi.org/10.1016/j.cmet.2023.12.025 | DOI Listing |
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