AI Article Synopsis
- The discovery of insulin around a century ago significantly improved diabetes management and reduced life-threatening complications like ketoacidosis, greatly benefiting patient health.
- There's a lingering negativity towards ketone bodies due to their association with ketoacidosis, even though they were once valued as crucial energy sources during fasting and exercise.
- Recent research is shifting perspectives on ketone bodies, exploring their potential roles in promoting longevity and their effects on various organs, including the heart, kidneys, muscles, and brain, as well as potential implications for cancer.
Article Abstract
The discovery of insulin approximately a century ago greatly improved the management of diabetes, including many of its life-threatening acute complications like ketoacidosis. This breakthrough saved many lives and extended the healthy lifespan of many patients with diabetes. However, there is still a negative perception of ketone bodies stemming from ketoacidosis. Originally, ketone bodies were thought of as a vital source of energy during fasting and exercise. Furthermore, in recent years, research on calorie restriction and its potential impact on extending healthy lifespans, as well as studies on ketone bodies, have gradually led to a reevaluation of the significance of ketone bodies in promoting longevity. Thus, in this review, we discuss the emerging and hidden roles of ketone bodies in various organs, including the heart, kidneys, skeletal muscles, and brain, as well as their potential impact on malignancies and lifespan.
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| http://dx.doi.org/10.1152/physiol.00031.2023 | DOI Listing |
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