AI Article Synopsis
- Malaria is a significant health issue in sub-Saharan Africa, with asymptomatic infections contributing to ongoing transmission challenges, especially as non-falciparum malaria becomes more prevalent.
- A study in Rwanda analyzed 4,596 individuals using quantitative PCR and found a 23.6% overall malaria infection rate, with asymptomatic falciparum malaria being widespread and low mixed-species infections common.
- The findings highlight the need for ongoing monitoring of malaria species, emphasizing the connection between falciparum infections and factors like socio-economic status and location.
Article Abstract
Background: Recent molecular surveillance suggests an unexpectedly high prevalence of non-falciparum malaria in Africa. Malaria control is also challenged by undetected asymptomatic malaria resulting in an undetectable reservoir for potential transmission. Context-specific surveillance of asymptomatic and non-falciparum species is needed to properly inform malaria control programs.
Methods: We performed quantitative real time PCR for four malaria species in 4,595 primarily adult individuals in Rwanda using the 2014-2015 Demographic Health Survey. We assessed correlates of infection by species to explore attributes associated with each species. Asymptomatic , malaria infection had broad spatial distribution across Rwanda. infection was rare.
Results: Overall infection prevalence was 23.6% (95%CI [21.7%, 26.0%]), with and non-falciparum at 17.6% [15.9%, 19.0%] and 8.3% [7.0%, 10.0%], respectively. Parasitemias tended to be low and mixed species infections were common, especially where malaria transmission and overall prevalence was the highest. infection was associated with lower wealth, rural residence and low elevation. Fewer factors were associated with non-falciparum malaria.
Conclusions: Asymptomatic non-falciparum malaria and malaria are common and widely distributed across Rwanda in adults. Continued molecular monitoring of is needed to strengthen malaria control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10802648 | PMC |
| http://dx.doi.org/10.1101/2024.01.09.24301054 | DOI Listing |
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