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Mseleni joint disease: an endemic arthritis of unknown cause.
Lancet Rheumatol
January 2020
Department of Human Biology, University of Cape Town, Cape Town 7925, South Africa. Electronic address:
Mseleni joint disease: a potential model of epigenetic chondrodysplasia.
Joint Bone Spine
October 2010
Department of Anthropology, Purdue University, West Lafayette, IN 47907, USA.
Objective: In this paper past research on the natural history of Mseleni joint disease, a crippling endemic osteoarthritis, its socio-economic impacts, the demographics, diet, geology and the genetic background of affected people are reviewed. In addition, some new research ideas are suggested to continue the search for etiological avenues for this disease such as stable isotope analysis and epigenetic mechanisms.
Results: Mseleni joint disease is a chondrodysplasia first described in 1970.
Mseleni and Handigodu familial osteoarthropathies: syndromic identity?
Am J Med Genet
November 1997
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Mseleni joint disease (MJD) and Handigodu joint disease (HJD) are familial skeletal disorders that affect several hundred persons in northern Zululand, South Africa and in the Shimoga district of southern India, respectively. Severe precocious, progressive degenerative osteoarthropathy, which occurs in both conditions, causes marked physical handicap by adulthood. The clinical and radiological manifestations of MJD and HJD are very similar and it is possible that they represent the same entity.
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