This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds -, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxidant capacity, cathepsin S inhibition, and interference with Nrf2 transcriptional activation. Of these MTDLs, emerged as a promising compound, demonstrating robust antioxidant activity, the ability to activate Nrf2-ARE pathways, as well as calcium channel blockade and cathepsin S inhibition. Dihydropyridine represents the first example of an MTDL that combines these biological activities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10819521 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics16010121 | DOI Listing |
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