AI Article Synopsis

  • Silicone endotracheal prostheses are good for medical use, but they often develop harmful biofilms that can cause inflammation and complications.
  • The study tested cold atmospheric plasma (CAP) to see if it could inhibit these harmful biofilms, and also assessed its effects on human bronchial cells.
  • Results showed that CAP significantly reduced biofilm viability without being harmful to the bronchial cells, suggesting it could be a useful method to prevent biofilm formation on silicone prostheses.

Article Abstract

Despite the excellent properties of silicone endotracheal prostheses, their main limitation is the formation of a polymicrobial biofilm on their surfaces. It can cause local inflammation, interfering with the local healing process and leading to further complications in the clinical scenario. The present study evaluated the inhibitory effect of cold atmospheric plasma (CAP) on multispecies biofilms grown on the silicone protheses' surfaces. In addition to silicone characterization before and after CAP exposure, CAP cytotoxicity on immortalized human bronchial epithelium cell line (BEAS-2B) was evaluated. The aging time test reported that CAP could temporarily change the silicone surface wetting characteristics from hydrophilic (80.5°) to highly hydrophilic (<5°). ATR-FTIR showed no significant alterations in the silicone surficial chemical composition after CAP exposure for 5 min. A significant log reduction in viable cells in monospecies biofilms (log CFU/mL) of , , and (0.636, 0.738, and 1.445, respectively) was detected after CAP exposure. Multispecies biofilms exposed to CAP showed significant viability reduction for and (1.385 and 0.831, respectively). The protocol was not cytotoxic to BEAS-2B. CAP can be a simple and effective method to delay multispecies biofilm formation inside the endotracheal prosthesis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10819505PMC
http://dx.doi.org/10.3390/microorganisms12010130DOI Listing

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