: The mechanisms involved in the development of brain metastasis (BM) remain elusive. Here, we investigated whether BM is associated with spine involvement in patients with non-small-cell lung cancer (NSCLC). : A consecutive 902 patients with metastatic NSCLC were included from the Inha Lung Cancer Cohort. Patients with BM at diagnosis or subsequent BM development were evaluated for both spine involvement in NSCLC and anatomic proximity of BM to the cerebrospinal fluid (CSF) space. At diagnosis, BM was found in 238 patients (26.4%) and bone metastasis was found in 393 patients (43.6%). In patients with bone metastasis, spine involvement was present in 280 patients. BM subsequently developed in 82 (28.9%) of 284 patients without BM at diagnosis. The presence of spine metastasis was associated with BM at diagnosis and subsequent BM development (adjusted odd ratios and 95% confidence intervals = 2.42 and 1.74-3.37, < 0.001; 1.94 and 1.19-3.18, = 0.008, respectively). Most patients with spine metastasis, either with BM at diagnosis or subsequent BM, showed BM lesions located adjacent (within 5mm) to the CSF space (93.8% of BM at the diagnosis, 100% of subsequent BM). These findings suggest that the presence of spine involvement is a risk factor for BM development in NSCLC patients with bone metastasis.
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http://dx.doi.org/10.3390/medicina60010152 | DOI Listing |
Eur Spine J
December 2024
Department of Orthopaedic Surgery, Columbia University Irving Medical Center, The Och Spine Hospital at NewYork Presbyterian, New York, NY, 10032, USA.
Purpose: To compare the long-term outcomes among AIS (10-18 years) and young AdIS (YAdIS) (19-40 years) patients with minimum 2 year follow up.
Methods: A retrospective review of AIS and YAdIS patients who underwent primary corrective surgery at a single center was conducted. Demographic, radiographic, operative data, patient reported outcome measures (PROMs), including the ODI and SRS-22r, and long-term complications were collected.
Global Spine J
December 2024
Department of Spine Surgery, Ganga Hospital, Coimbatore, India.
Study Design: Prospective analysis of retrospective data.
Objectives: To analyse the clinical and radiological outcomes of thoracic and thoracolumbar TB kyphosis by a posterior-only approach using kyphosis classification.
Methods: Patients with thoracic and thoracolumbar spinal TB who underwent posterior-only surgical correction for kyphotic deformity >30° were categorized into Group: A (Active TB) and Group B (Healed TB).
Cureus
November 2024
Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, JPN.
Introduction: The ZAP-X® Gyroscopic Radiosurgery System (ZAP Surgical Systems, Inc., San Carlos, CA, USA) is expected to be a highly accurate next-generation treatment system that enables gyro-stereotactic irradiation of intracranial lesions. In this study, we report the initial treatment course using ZAP-X for intracranial lesions that recurred after Gamma Knife (GK) treatment.
View Article and Find Full Text PDFCureus
November 2024
Physical Medicine and Rehabilitation, Hospital Curry Cabral, Unidade Local de Saúde de São José, Lisbon, PRT.
Introduction: Spondylodiscitis is a rare but increasingly infectious disease affecting the intervertebral discs and vertebrae.
Methods: This study retrospectively analyzed 36 patients admitted with spondylodiscitis over a five-year period, examining demographics, clinical features, risk factors, causative agents, treatment approaches, and outcomes.
Results: The patient cohort had a mean age of 53.
Background Low back pain (LBP) is the leading cause of disability among working-age adults, with its prevalence increasing with age and peaking in the 45-54 age group. It is common practice for clinicians to conduct advanced imaging procedures, such as computed tomography (CT) and magnetic resonance imaging (MRI) when a patient presents with LBP. The objective of this study was to measure and analyze the width of the ligamentum flavum (LF) on each side and the extent of degeneration of the disc at the L3-4, L4-5, and L5-S1 levels.
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