AI Article Synopsis
- Chronic kidney disease leads to reduced kidney function and is associated with complications like inflammation and electrolyte imbalances, which can increase cardiovascular risks.
- Cardiovascular issues, particularly ischemic heart problems, are a major cause of death in patients with chronic kidney disease, indicating a link between the two conditions.
- The study aims to explore this relationship by identifying specific biomarkers that could help with diagnosis and treatment, focusing on various proteins that indicate heart and kidney health.
Article Abstract
Chronic kidney disease represents a complex and multifaceted pathology characterized by the presence of structural or functional renal anomalies associated with a persistent reduction in renal function. As the disease progresses, complications arise due to the chronic inflammatory syndrome, hydro-electrolytic disorders, and toxicity secondary to the uremic environment. Cardiovascular complications are the leading cause of death for these patients. Ischemic cardiac pathology can be both a consequence and complication of chronic kidney disease, highlighting the need to identify specific cardiorenal dysfunction biomarkers targeting pathophysiological mechanisms common to both conditions. This identification is crucial for establishing accurate diagnoses, prognoses, and risk stratifications for patients. This work is intended to elucidate the intricate relationship between chronic kidney disease and ischemic heart disease and to investigate the roles of cardiorenal biomarkers, including cardiac troponin, natriuretic peptides, galectin-3, copeptin, fibroblast growth factor 23 and its co-receptor Klotho, soluble suppression of tumorigenicity 2, and plasma growth differentiation factor 15.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817293 | PMC |
| http://dx.doi.org/10.3390/life14010034 | DOI Listing |
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