AI Article Synopsis

  • - This study examined how well radiographic scores and lab markers can predict rapid worsening of COVID-19 pneumonia in hospitalized patients, focusing on 218 cases.
  • - Rapid progression, defined as needing mechanical ventilation within a week of admission, was found in 9.6% of patients, with the QMD score being the most effective predictor.
  • - The research highlighted that even after negative COVID tests, some patients had lingering lung issues, emphasizing the importance of using AI-driven CT scores and lab data for monitoring and predicting disease progression.

Article Abstract

Coronavirus disease 2019 (COVID-19), is an ongoing issue in certain populations, presenting rapidly worsening pneumonia and persistent symptoms. This study aimed to test the predictability of rapid progression using radiographic scores and laboratory markers and present longitudinal changes. This retrospective study included 218 COVID-19 pneumonia patients admitted at the Chungnam National University Hospital. Rapid progression was defined as respiratory failure requiring mechanical ventilation within one week of hospitalization. Quantitative COVID (QCOVID) scores were derived from high-resolution computed tomography (CT) analyses: (1) ground glass opacity (QGGO), (2) mixed diseases (QMD), and (3) consolidation (QCON), and the sum, quantitative total lung diseases (QTLD). Laboratory data, including inflammatory markers, were obtained from electronic medical records. Rapid progression was observed in 9.6% of patients. All QCOVID scores predicted rapid progression, with QMD showing the best predictability (AUC = 0.813). In multivariate analyses, the QMD score and interleukin(IL)-6 level were important predictors for rapid progression (AUC = 0.864). With >2 months follow-up CT, remained lung lesions were observed in 21 subjects, even after several weeks of negative reverse transcription polymerase chain reaction test. AI-driven quantitative CT scores in conjugation with laboratory markers can be useful in predicting the rapid progression and monitoring of COVID-19.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10813449PMC
http://dx.doi.org/10.3390/biomedicines12010120DOI Listing

Publication Analysis

Top Keywords

rapid progression
28
laboratory markers
12
computed tomography
8
scores laboratory
8
longitudinal changes
8
2019 covid-19
8
covid-19 pneumonia
8
qcovid scores
8
rapid
7
progression
7

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!