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Using T-Cell Subsets to Better Characterize Immunoresiliency and Immunodeficiency in Patients with Recurrent Infections.
Infect Dis Rep
December 2024
Department of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Background/objectives: Common Variable Immunodeficiency Disease (CVID) and other immunodeficiencies can present in subtle and variable ways. Whether or not a genetic lesion can be identified, there are not well understood biomarkers that quantitatively describe how severe a deficiency is. Here we discuss two possible ranking systems, CD4/CD8 T cell ratios and Immune Health Grades, and how such data maybe applicable to some immunodeficiencies.
View Article and Find Full Text PDFResponse to Comment on A Method for Continuous Surgeon Improvement in Rectal Cancer.
Ann Surg Open
December 2024
From the Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN.
Adolescent experiences of weight-related communication: Sociodemographic differences and the role of parents.
Pediatr Obes
February 2025
WW International, Inc, New York City, New York, USA.
Background: Weight-related conversations are common between adolescents and parents. However, there is limited understanding of how these conversations vary across sociodemographic groups, such as sex, sexual orientation, race/ethnicity, or parents' level of education. This study assessed the prevalence of weight-related communication among adolescents and parents across sociodemographic characteristics, and identified adolescents' preferred sources for these discussions.
View Article and Find Full Text PDFExpectations and experiences of pain during medical abortion at home: a secondary, mixed-methods analysis of a patient survey in England and Wales.
BMJ Sex Reprod Health
December 2024
Centre for Reproductive Research & Communication, British Pregnancy Advisory Service, London, UK.
Objective: To explore experiences of pain during medical abortion and provide patient-centred recommendations for improving abortion experience and pain counselling.
Methods: We invited patients of British Pregnancy Advisory Service who underwent medical abortion up to 10 weeks' gestation to participate in an online, English language questionnaire from November 2021 to March 2022. Participants answered questions about pain, method preference, abortion experience, advice, and how they would describe pain experienced to a friend.
Apical hook opening of plant seedlings: Unfolding the role of auxin and the cell wall.
Dev Cell
December 2024
Department of Biology, Duke University, Durham, NC 27708, USA; Duke Center for Quantitative BioDesign, Durham, NC 27708, USA. Electronic address:
Apical hook opening is crucial for seedling establishment and is regulated by unequal distribution of the hormone auxin through unknown mechanisms. In this issue of Developmental Cell, Walia et al. demonstrate that apical hook opening is an output of tissue-wide forces; auxin and cell wall integrity (CWI) signaling interact to restrict elongation to the concave side of the apical hook.
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