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Genome-wide analyses provide insights into genetic variation, phylo- and co-phylogenetic relationships, and biogeography of the entomopathogenic nematode genus Heterorhabditis.
Mol Phylogenet Evol
January 2025
Laboratory of Diagnosis and Integrated Management of Plant Bio-Aggressors. University of Parakou, BP123 Parakou, Borgou, Benin.
Multigene, genus-wide phylogenetic studies have uncovered the limited taxonomic resolution power of commonly used gene markers, particularly of rRNA genes, to discriminate closely related species of the nematode genus Heterorhabditis. In addition, conflicting tree topologies are often obtained using the different gene markers, which limits our understanding of the phylo- and co-phylogenetic relationships and biogeography of the entomopathogenic nematode genus Heterorhabditis. Here we carried out phylogenomic reconstructions using whole nuclear and mitochondrial genomes, and whole ribosomal operon sequences, as well as multiple phylogenetic reconstructions using various single nuclear and mitochondrial genes.
View Article and Find Full Text PDFGenome-wide comparative analysis of clinical and environmental strains of the opportunistic pathogen ().
Front Microbiol
November 2024
Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Article Synopsis
- The study focuses on a specific bacterial species that can cause opportunistic infections in humans, making it a useful model for understanding how bacteria can switch from living harmlessly to becoming pathogenic.
- Researchers conducted a comprehensive analysis of the genomic sequences of seven bacterial isolates, discovering a complex structure with several extrachromosomal elements, including a new type of mobile genetic element.
- Key findings include the identification of unique virulence genes, notably the URE gene cluster related to ureolytic activity, highlighting the significance of the flexible genome in influencing the bacterium's ability to cause infections.
Antimicrobial and Anti-Inflammatory Potential of (L.): a bioprospecting study with phytoconstituents analysis.
J Pharmacopuncture
September 2024
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Mutah University, Al-Karak, Jordan.
Objectives: The phytochemicals in the aerial parts of (also known as Sea Spurge) and their anti-inflammatory and antimicrobial activities were investigated.
Methods: The methanolic extract was characterized using GC-MS and HPLC techniques. The anti-inflammatory feature was estimated through a Human Red Blood Cell (HRBC) membrane stabilization technique, while the antimicrobial feature was evaluated by the disc diffusion agar technique, minimum bactericidal concentration, and minimum inhibitory concentration (MIC) micro-broth dilution method.
Genomic oropharyngeal surveillance detects MALDI-TOF MS species misidentifications and reveals a novel clade.
J Med Microbiol
August 2024
Department of Clinical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium.
Article Synopsis
- Commensal species are commonly found in the oropharynx as part of the healthy microbiome but can also lead to serious diseases like meningococcal disease.
- Clinical microbiology labs often use MALDI-TOF MS for species identification but can misidentify certain bacteria, which highlights the need for genomic surveillance to verify these results.
- A study in Belgium analyzed 119 bacterial isolates using genome sequencing and different identification methods, revealing discrepancies in MALDI-TOF MS results and demonstrating the significance of comprehensive genomic analysis for correctly identifying and understanding these species.
Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera , , , and across Türkiye.
J Proteome Res
August 2024
Institut für Chemie, Technische Universität Berlin, Straße des 17. Juni 135, 10623 Berlin, Germany.
Snake venom variations are a crucial factor to understand the consequences of snakebite envenoming worldwide, and therefore it is important to know about toxin composition alterations between taxa. Palearctic vipers of the genera , , and have high medical impacts across the Old World. One hotspot for their occurrence and diversity is Türkiye, located on the border between continents, but many of their venoms remain still understudied.
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