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From knife to needle - the trend of vascular neurosurgery in Belgium.
Brain Spine
December 2024
Department of Neurosurgery, Universitair Ziekenhuis Brussel (UZ Brussel) - Vrije Universiteit Brussel (VUB), Laarbeeklaan 101-103, 1090, Brussels, Belgium.
Introduction: The management of neurovascular pathologies has changed globally over the last few decades. Endovascular treatments are increasing, and fewer surgical procedures are performed.
Research Question: Evaluate the evolution of vascular neurosurgery in Belgium over the last 30 years and compare with other countries.
Development and Validation of a Rapid Point-of-Care CYP2C19 Genotyping Platform.
J Mol Diagn
December 2024
Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Division of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester, United Kingdom. Electronic address:
Pharmacogenetic-guided prescribing can lead to more accurate medicine selection and dosing, improving patient outcomes and leading to better use of health care budgets. Loss-of-function variants in CYP2C19 influence an individual's ability to metabolize clopidogrel, increasing the risk of secondary vascular events following ischemic stroke and percutaneous coronary intervention. In acute clinical contexts, centralized laboratory-based testing is too slow to inform timely clinical decision-making.
View Article and Find Full Text PDFSurgery of brainstem cavernous malformations: surgical nuances and outcomes of a monocentric series of 34 patients.
Neurol Sci
December 2024
Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
Background: Brainstem cavernous malformations (BCM) constitute one of the most controversial and challenging neurological pathologies: both natural course and surgical manipulation can lead to severe neurological symptoms by direct compression or following hemorrhage of this highly eloquent brain region.
Methods: The vascular section of the prospectively collected neurosurgical database of our center (2011-2023) was retrospectively reviewed, seeking all patients operated on for a sporadic BCM. Clinical, radiological and surgical data, operative records and videos were analyzed by independent reviewers with the assistance of a dedicated neuropsychologist, blinded to the hospital course.
Revolutionizing Limb Preservation: A Case Report on Recurrent Fungating Giant Cell Tumor with Encased Radial Artery in the Distal Radius.
J Orthop Case Rep
December 2024
Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Giant cell tumor (GCT) of the bone, although benign, poses significant challenges due to its locally aggressive nature and high recurrence rates post-surgical intervention. Among skeletal GCTs, those affecting the distal radius present unique difficulties, especially when fungating masses encase vital structures such as blood vessels.
Case Report: We present a case of a 28-year-old male with a recurring GCT of the distal radius, where limb-preserving surgery was successfully performed despite encasement of the radial artery.
Infarctive encephalopathy in zoo-housed gibbons in North America.
Vet Pathol
December 2024
Cornell University, Ithaca, NY.
Progressive neurologic signs without a known underlying etiology have been observed in managed gibbon populations housed at institutions in North America. In 2018, the Gibbon Species Survival Plan initiated a veterinary survey to evaluate clinical histories among gibbons displaying neurologic signs. The clinical results of this survey as well as the results of a centralized histologic review of brain samples from 5 species of managed gibbons displaying neurologic signs are outlined here.
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