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Article Synopsis
  • The study aims to improve the diagnosis and understanding of "potentially malignant" diseases affecting the oral mucosa, focusing on patients aged 35 to 80.
  • It involved clinical and laboratory evaluations of 124 patients with various conditions, employing methods like histological analysis and the Ki-67 index for cell activity.
  • Results showed high p53 mutation prevalence in erythroplakia, significant Ki-67 and p16INK4a expression in leukoplakia, and suggested that combined histological and immunohistochemical techniques are essential for early detection of neoplastic changes.
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A special program aimed at detecting skin cancer at early stages was worked out and launched into use in 1989. It provides for a series of measures for primary examination and subsequent follow-up of population. Dermatologists conducted examinations of persons at high risk 2-4 times a year depending on the disease.

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