Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (-)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid ()], and four biphenyl derivatives [garcilatelibiphenyls A-D (-)] were newly isolated in a phytochemical study of a 50% MeOH/CHCl extract of (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC values from 0.5 to 6.7 μM against all tested tumor cell lines.
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| http://dx.doi.org/10.1021/acs.jnatprod.3c00934 | DOI Listing |
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