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A novel injection device to administer repository corticotropin injection for inflammatory disease treatment: findings from a market research study.
J Comp Eff Res
December 2024
Mallinckrodt Pharmaceuticals, Bridgewater, NJ 08807, USA.
The goal of this market research study was to determine the usability of a single-dose prefilled injector (SelfJect™) for administration of Acthar Gel (manufactured by Mallinckrodt Pharmaceuticals, UK) in patients with inflammatory diseases by obtaining feedback from patient and practitioner user groups in the US. Patients and healthcare professionals (HCPs) representing relevant therapeutic areas were enrolled in the study between February and March 2021. SelfJect was mailed to patients and HCPs prior to 90-min virtual video-recorded focus group sessions and 60-min 1:1 virtual interviews, respectively.
View Article and Find Full Text PDFEligibility and Endpoints for Clinical Trials in Trimodality Therapy for Bladder Cancer.
Bladder Cancer
October 2024
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Trimodality therapy (TMT) is a viable option for muscle-invasive localized bladder cancer, providing an alternative to radical cystectomy in properly selected patients. The approval of novel therapeutics in different stages of bladder cancer treatment has sparked interest in exploring concurrent systemic therapies with radiation in clinical trials to enhance long-term outcomes. Achieving uniformity in trial eligibility criteria and endpoint definitions is imperative in describing clinical significance, comparing trials, and changing standard of care guidelines.
View Article and Find Full Text PDFCancer Drug Wastage and Mitigation Methods: A Systematic Review.
Value Health
September 2024
Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:
Article Synopsis
- The study systematically reviews evidence on cancer drug wastage and the effectiveness of various mitigation methods, assessing articles from databases like Scopus, PubMed, and EMBASE.
- Out of 6298 articles, 94 were included, with most focusing on high-income countries and recent publications, revealing that a significant number report on mitigation methods like vial sharing and dose rounding.
- Findings show that cancer drug wastage costs are notably higher in the US compared to other countries, emphasizing the need for better reporting standards for drug wastage in future research to improve healthcare expenditure efficiency.
Impact of Disease Factors of Patients with Psoriasis and Psoriatic Arthritis on Biologic Therapy Switching: Real-World Evidence from the CorEvitas Psoriasis Registry.
Dermatol Ther (Heidelb)
October 2024
Department of Dermatology, Mount Sinai-The Icahn School of Medicine at Mt. Sinai, 5 East 98th St 5th Fl, New York, NY, 10029, USA.
Introduction: Patients with psoriasis (PSO) and psoriatic arthritis (PsA) may frequently switch biologic therapies over the course of treatment because of symptom variability and individual responses. Real-world studies analyzing patient characteristics and clinical factors associated with biologic switching are limited.
Methods: This longitudinal cohort study used real-world data from the CorEvitas Psoriasis Registry to evaluate the relationship between associated disease factors and biologic switching among patients with PSO and PsA in the United States (US) and Canada following initiation of a biologic.
Development of a Consensus Guideline for the Diagnosis and Management of Chronic Noninfectious Uveitis Affecting the Posterior Segment.
Ophthalmic Surg Lasers Imaging Retina
November 2024
Background And Objective: A consensus exercise was carried out to address unmet needs in the classification, diagnosis, and management of patients with chronic noninfectious uveitis affecting the posterior segment (NIU-PS), with a focus on chronic postoperative inflammation/cystoid macular edema.
Methods: Eight experts participated in roundtable discussions and consensus-building exercises to develop clear guidelines for the diagnosis and management of chronic NIU-PS. The group addressed questions surrounding clinical features, diagnostic tests, and treatment considerations.
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