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Evolving landscape of treatments targeting the microenvironment of liver metastases in non-small cell lung cancer. | LitMetric

Evolving landscape of treatments targeting the microenvironment of liver metastases in non-small cell lung cancer.

Chin Med J (Engl)

Lung Cancer Center, Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Published: May 2024

AI Article Synopsis

  • Liver metastases (LMs) are frequently found in lung cancer cases, contributing to low survival rates due to the liver's immune-suppressive environment that helps tumor cells escape detection.
  • Recent studies have focused on how LMs affect the effectiveness of immune checkpoint inhibitors and the signals produced by different liver cells that contribute to tumor progression.
  • The review covers the epidemiology, physiology, and immunology of LMs in non-small cell lung cancer, highlighting current and future treatment strategies that combine immunotherapy with other treatments to tackle liver-related immune suppression.

Article Abstract

Liver metastases (LMs) are common in lung cancer. Despite substantial advances in diagnosis and treatment, the survival rate of patients with LM remains low as the immune-suppressive microenvironment of the liver allows tumor cells to evade the immune system. The impact of LMs on the outcomes of immune checkpoint inhibitors in patients with solid tumors has been the main focus of recent translational and clinical research. Growing evidence indicates that the hepatic microenvironment delivers paracrine and autocrine signals from non-parenchymal and parenchymal cells. Overall, these microenvironments create pre- and post-metastatic conditions for the progression of LMs. Herein, we reviewed the epidemiology, physiology, pathology and immunology, of LMs associated with non-small cell lung cancer and the role and potential targets of the liver microenvironment in LM in each phase of metastasis. Additionally, we reviewed the current treatment strategies and challenges that should be overcome in preclinical and clinical investigations. These approaches target liver elements as the basis for future clinical trials, including combinatorial interventions reported to resolve hepatic immune suppression, such as immunotherapy plus chemotherapy, immunotherapy plus radiotherapy, immunotherapy plus anti-angiogenesis therapy, and surgical resection.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062672PMC
http://dx.doi.org/10.1097/CM9.0000000000002981DOI Listing

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