AI Article Synopsis
- Infections caused by certain bacteria are hard to treat due to high antibiotic resistance and biofilm formation, leading to a need for new treatments.
- The study investigated the antimicrobial and antibiofilm effects of rice husk extract (RHE) on methicillin-resistant and sensitive clinical isolates, showing that RHE could inhibit biofilm formation.
- RHE proved safe for use in live larvae and showed potential for future applications in topical solutions or medical devices to combat biofilm-related issues.
Article Abstract
Infections caused by are particularly difficult to treat due to the high rate of antibiotic resistance. also forms biofilms that reduce the effects of antibiotics and disinfectants. Therefore, new therapeutic approaches are increasingly required. In this scenario, plant waste products represent a source of bioactive molecules. In this study, we evaluated the antimicrobial and antibiofilm activity of the rice husk extract (RHE) on clinical isolates. In a biofilm inhibition assay, high concentrations of RHE counteracted the formation of biofilm by isolates, both methicillin-resistant (MRSA) and -sensitive (MSSA). The observation of the MRSA biofilm by confocal laser scanning microscopy using live/dead cell viability staining confirmed that the bacterial viability in the RHE-treated biofilm was reduced. However, the extract showed no or little biofilm disaggregation ability. An additive effect was observed when treating with a combination of RHE and oxacillin/cefoxitin. In larvae treated with RHE, the extract showed no toxicity even at high concentrations. Our results support that the rice husk has antimicrobial and antibiofilm properties and could potentially be used in the future in topical solutions or on medical devices to prevent biofilm formation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10820005 | PMC |
| http://dx.doi.org/10.3390/pathogens13010080 | DOI Listing |
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