Another Step Forward for Freezing of Gait in Parkinson's Disease.

J Parkinsons Dis

Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.

Published: March 2024

The study "A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease" by Milekovic et al. introduces a novel neuroprosthesis for treating locomotor deficits in late-stage Parkinson's disease (PD). This approach employs an epidural spinal array targeting dorsal roots and electromyography to create a spatiotemporal map of muscle activation, aiming to restore natural gait patterns. Significant improvements in gait freezing and balance were observed in both non-human primate models and a human patient, resulting in improved mobility and quality of life. This innovative method, integrating real-time feedback and non-invasive motor intention decoding, marks a significant advancement in PD treatment.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977400PMC
http://dx.doi.org/10.3233/JPD-230412DOI Listing

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