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Cutaneous Mastocytosis in Pediatric Patients With Skin of Color: A Retrospective Cohort Study.
Pediatr Dermatol
January 2025
Division of Dermatology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Cutaneous mastocytosis (CM) is a rare skin disease with limited data on its prevalence across different racial groups. This retrospective cohort study examines the characteristics of CM at Nationwide Children's Hospital (NCH) from January 2010 to June 2022, identifying 192 confirmed cases of CM and further stratifying this cohort to 155 patients with documented Fitzpatrick phototypes. There were two important findings: first, nine (4.
View Article and Find Full Text PDFExploring canine mast cell tumors: An investigation into demographic characteristics, and grading system analysis from a pathology lab data (2019-2021).
Prev Vet Med
March 2025
DNAtech, Laboratório Veterinário, Lisboa, Portugal; CECAV, Centro de Ciência Animal e Veterinária, Faculdade de Medicina Veterinária, Universidade Lusófona-Centro Universitário de Lisboa, Portugal; CBIOS - Centro de Investigação em Biociências e Tecnologias da Saúde - Universidade Lusófona, Lisboa, Portugal.
Mast cell tumors (MCT) are among the most common neoplasia in dogs, representing up to 21 % of skin tumors. However, etiology and risk factors for its development remain unclear. This study aimed to reduce this knowledge gap by comprehensively analyzing 905 MCT cases diagnosed in Portugal between 2019 and 2021, using descriptive and inferential analyses.
View Article and Find Full Text PDFExploring Pediatric Dermatology in Skin of Color: Focus on Dermoscopy.
Life (Basel)
December 2024
Institute of Dermatology, Department of Medical Area, University of Udine, 33100 Udine, Italy.
This literature review aims to comprehensively evaluate the clinical and dermoscopic presentations of common pediatric diseases among children with skin of color (SoC) while also addressing potential variations based on racial backgrounds. This review encompasses various conditions, such as nevi subtypes, viral infections, infestations, and inflammatory dermatoses, as well as hair diseases and abnormal vascular formations, occurring in pediatric populations. Overall, we identified 7 studies on nevi subtypes, 24 studies on skin infections, 6 on inflammatory dermatoses, 10 on hair diseases and disorders, and 14 on miscellaneous disorders that also satisfied our SoC- and race-specific criteria.
View Article and Find Full Text PDFComparison of sentinel lymph node mapping patterns before and after surgical excision of mast cell tumors in dogs using indirect lymphography: A prospective clinical study.
Can J Vet Res
January 2025
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Auburn University, 1220 Wire Road, Auburn, Alabama 36849-5540, USA.
Article Synopsis
- Sentinel lymph node (SLN) mapping is crucial for staging dogs with mast cell tumors (MCTs), but many are referred to oncologists after surgery.
- A study involving 29 dogs aimed to see if lymphatic drainage patterns change before and after tumor removal by comparing SLN mapping results.
- The findings showed that surgical intervention did affect lymphatic drainage, with only 46.7% of cases showing complete agreement in SLN identification before and after surgery.
Flow Cytometry for the Detection and Quantification of Mast Cells in Lymph Nodes: A Prospective Study in 64 Dogs With Mast Cell Tumour.
Vet Comp Oncol
March 2025
Department of Veterinary Sciences, University of Turin, Turin, Italy.
Nodal metastasis is a negative prognostic factor in dogs with mast cell tumours (MCTs), thus early detection enables more informed decision-making and provides valuable prognostic information. The aim of this study is to assess the concordance between histopathologic findings of LNs and cytology and flow cytometry (FC), respectively, and to evaluate the ability of FC to differentiate between metastatic (HN2-HN3) and non-metastatic (HN0-HN1) LNs. Overall, 117 LNs from 64 dogs with first occurring MCTs were submitted for cytology, histology and FC.
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