AI Article Synopsis
- Natural killer T cells (NKTs) are unique immune cells found mostly in the liver, playing a crucial role in liver immunity by expressing both NK and T cell markers.
- They are classified into Type I and Type II based on TCR usage, responding to lipid antigens via the CD1d molecule and can rapidly produce cytokines to influence immune responses in various ways.
- The review highlights the role of NKT cell subpopulations in liver transplantation immunity, addressing challenges in current research while also touching on CD56-expressing T cells, a group that resembles NKTs.
Article Abstract
Natural killer T cells (NKTs) are innate-like lymphocytes that are abundant in the liver and participate in liver immunity. NKT cells express both NK cell and T cell markers, modulate innate and adaptive immune responses. Type I and Type II NKT cells are classified according to the TCR usage, while they recognize lipid antigen in a non-classical major histocompatibility (MHC) molecule CD1d-restricted manner. Once activated, NKT cells can quickly produce cytokines and chemokines to negatively or positively regulate the immune responses, depending on the different NKT subsets. In liver transplantation (LTx), the immune reactions in a series of processes determine the recipients' long-term survival, including ischemia-reperfusion injury, alloresponse, and post-transplant infection. This review provides insight into the research on NKT cells subpopulations in LTx immunity during different processes, and discusses the shortcomings of the current research on NKT cells. Additionally, the CD56-expressing T cells are recognized as a NK-like T cell population, they were also discussed during these processes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796773 | PMC |
| http://dx.doi.org/10.3389/fcell.2023.1274361 | DOI Listing |
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