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Non-steroidal anti-inflammatory drug induced intestinal stricturing: diaphragm disease. | LitMetric

Non-steroidal anti-inflammatory drug induced intestinal stricturing: diaphragm disease.

J Surg Case Rep

John Goligher Colorectal Surgery Unit, St James's University Hospital, Leeds LS9 7TF, United Kingdom.

Published: January 2024

AI Article Synopsis

  • - Diaphragm disease (DD) is a rare condition linked to the use of non-steroidal anti-inflammatory drugs, with only about 100 documented cases.
  • - It leads to the formation of stricturing webs in the small intestine, resulting in vague abdominal symptoms that may escalate to bleeding and obstruction.
  • - Diagnosis of DD is difficult due to the lack of a definitive test, but the paper discusses two instances diagnosed via surgery and suggests a new flow algorithm for evaluating suspected cases.

Article Abstract

Diaphragm disease (DD) is a rare small bowel enteropathy associated with non-steroidal anti-inflammatory drug use. Since the first description there have only been approximately 100 cases of DD reported in the literature. Stricturing webs or 'diaphragms' form in the bowel, causing non-specific abdominal symptoms that can ultimately lead to bleeding and obstruction. Diagnosis is notoriously challenging as there is no single gold standard investigation. We present two cases of DD both of which were ultimately diagnosed by surgical resection. We also propose a novel flow algorithm that can be utilized for working up patients with suspected DD.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10799247PMC
http://dx.doi.org/10.1093/jscr/rjad489DOI Listing

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