Measurement models traditionally make the assumption that item responses are independent from one another, conditional upon the common factor. They typically explore for violations of this assumption using various methods, but rarely do they account for the possibility that an item predicts the next. Extending the development of auto-regressive models in the context of personality and judgment tests, we propose to extend binary item response models-using, as an example, the 2-parameter logistic (2PL) model-to include auto-regressive sequential dependencies. We motivate such models and illustrate them in the context of a publicly available progressive matrices dataset. We find an auto-regressive lag-1 2PL model to outperform a traditional 2PL model in fit as well as to provide more conservative discrimination parameters and standard errors. We conclude that sequential effects are likely overlooked in the context of cognitive ability testing in general and progressive matrices tests in particular. We discuss extensions, notably models with multiple lag effects and variable lag effects.
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http://dx.doi.org/10.3390/jintelligence12010007 | DOI Listing |
J Comput Chem
January 2025
Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, CDMX, Mexico.
The G protein-coupled receptor (GPCR) pharmacology accounts for a significant field in research, clinical studies, and therapeutics. Computer-aided drug discovery is an evolving suite of techniques and methodologies that facilitate accelerated progress in drug discovery and repositioning. However, the structure-activity relationships of molecules targeting GPCRs are highly challenging in many cases since slight structural modifications can lead to drastic changes in biological functionality.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Polymers and Pigments Department, Chemical Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt.
Integrating nanotechnology with tissue engineering has revolutionized biomedical sciences, enabling the development of advanced therapeutic strategies. Tissue engineering applications widely utilize alginate due to its biocompatibility, mild gelation conditions, and ease of modification. Combining different nanomaterials with alginate matrices enhances the resulting nanocomposites' physicochemical properties, such as mechanical, electrical, and biological properties, as well as their surface area-to-volume ratio, offering significant potential for tissue engineering applications.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, United States.
Single-cell technologies have enabled the high-dimensional characterization of cell populations at an unprecedented scale. The innate complexity and increasing volume of data pose significant computational and analytical challenges, especially in comparative studies delineating cellular architectures across various biological conditions (i.e.
View Article and Find Full Text PDFBMC Bioinformatics
January 2025
Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital of Capital Medical University, Beijing, 101100, China.
Background: MicroRNAs (miRNAs) are pivotal in the initiation and progression of complex human diseases and have been identified as targets for small molecule (SM) drugs. However, the expensive and time-intensive characteristics of conventional experimental techniques for identifying SM-miRNA associations highlight the necessity for efficient computational methodologies in this field.
Results: In this study, we proposed a deep learning method called Multi-source Data Fusion and Graph Neural Networks for Small Molecule-MiRNA Association (MDFGNN-SMMA) to predict potential SM-miRNA associations.
ACS Biomater Sci Eng
January 2025
Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions, ranging from hepatic steatosis to steatohepatitis, fibrosis, and severe outcomes such as cirrhosis or cancer. The progression from hepatic steatosis to fibrosis involves significant extracellular matrix (ECM) remodeling, characterized by increased collagen deposition and cross-linking of ECM proteins, causing increased tissue stiffness and altered MMP expression patterns. Dysregulated MMP expression and extracellular acidosis are key contributors to NAFLD progression.
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