AI Article Synopsis
- A 72-year-old man undergoing chemotherapy for multiple myeloma experienced testicular swelling 3 years after diagnosis.
- Following a high orchiectomy, he was diagnosed with plasmacytoma, prompting treatment with isatuximab and dexamethasone.
- Current follow-up shows no recurrence, highlighting the importance of pathological evaluation for accurate diagnosis and treatment in rare testicular tumors.
Article Abstract
A 72-year-old male patient, who had been on chemotherapy for the treatment of IgG-λ multiple myeloma, presented an enlargement of the testis 3 years and 5 months after the diagnosis. High orchiectomy was then performed, leading to the diagnosis of plasmacytoma. Due to residual disease, treatment with a combination of isatuximab and dexamethasone was initiated. The patient is currently under follow-up without recurrence. While testicular tumors are difficult to diagnose by imaging studies alone and extramedullary plasmacytomas rarely occur in the testis, pathological assessment is critical for treatment planning.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Safranal ameliorates testicular ischemia-reperfusion injury in testicular torsion-detorsion rat model.
Rev Int Androl
December 2024
Department of Sports Science, College of Education, Zhejiang University, 310058 Hangzhou, Zhejiang, China.
Background: Testicular torsion-detorsion damage is a common ischemia-reperfusion injury brought on by an excess of reactive oxygen species. Reactive oxygen species may affect cellular differentiation by regulating gene expression. The gene expression in the testis is essential for spermatogenesis.
View Article and Find Full Text PDFThe Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility.
J Dev Biol
November 2024
Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Barth syndrome (BTHS) is a rare, infantile-onset, X-linked mitochondriopathy exhibiting a variable presentation of failure to thrive, growth insufficiency, skeletal myopathy, neutropenia, and heart anomalies due to mitochondrial dysfunction secondary to inherited TAFAZZIN transacetylase mutations. Although not reported in BTHS patients, male infertility is observed in several () mouse alleles and in a mutant. Herein, we examined the male infertility phenotype in a BTHS-patient-derived point-mutant knockin mouse () allele that expresses a mutant protein lacking transacetylase activity.
View Article and Find Full Text PDFPure Yolk Sac Testicular Tumour in an Adult: A Diagnostic Dilemma.
Cureus
November 2024
Andrology, University College London, London, GBR.
A rare case of a pure yolk sac testicular tumour presenting in an adult with learning difficulties is presented. Pure yolk sac tumours are much more common in children, but when they do occur in adults, onset can be both insidious and aggressive. The best practice for identification involves the precise use of ultrasound, blood tests for tumour markers and FDG-PET/CT imaging for staging.
View Article and Find Full Text PDFSaffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
J Ethnopharmacol
December 2024
Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China; Department of Urology, Shandong Provincial Hospital, Associated with Shandong University, Jinan, 250021, China; College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250199, China; Key Laboratory of Urinary Diseases in Universities of Shandong, Shandong First Medical University, Jinan, 250021, China. Electronic address:
Ethnopharmacological Relevance: Late-onset hypogonadism (LOH) is a common age-related condition in men, characterized by a decline in serum testosterone and a range of associated signs and symptoms, and is classified as impotence in traditional medicine. Saffron is the dried stigma of Crocus sativus L., which is used in traditional medicine as an aphrodisiac.
View Article and Find Full Text PDFAutoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria.
Ann Clin Transl Neurol
December 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Objective: We describe neurologic phenotype, clinical associations, and outcomes in autoimmune brainstem encephalitis.
Methods: Medical records of neural-IgG positive autoimmune brainstem encephalitis patients diagnosed at Mayo Clinic (January 1, 2006-December 31, 2022) were reviewed.
Results: Ninety-eight patients (57 male) were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!