AI Article Synopsis
- - Fibrotic pulmonary sarcoidosis (fPS) impacts about 20% of patients and is associated with significant health risks and variable prognosis based on factors like fibrosis extent and functional impairment severity.
- - The condition is also affected by complications such as acute exacerbations and infections, but its natural progression, particularly the risk of ongoing fibrosis, remains unclear.
- - Managing fPS is complex and may involve anti-inflammatory treatments, rehabilitation, and, in certain cases, antifibrotic therapy or lung transplantation.
Article Abstract
Fibrotic pulmonary sarcoidosis (fPS) affects about 20% of patients. fPS carries a significant morbidity and mortality. However, its prognosis is highly variable, depending mainly on fibrosis extent, functional impairment severity, and the development of pulmonary hypertension. Moreover, fPS outcomes are also influenced by several other complications, including acute exacerbations, and infections. fPS natural history is unknown, in particular regarding the risk of progressive self-sustaining fibrosis. The management of fPS is challenging, including anti-inflammatory treatment if granulomatous activity persists, rehabilitation, and in highly selected patients antifibrotic treatment and lung transplantation.
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| http://dx.doi.org/10.1016/j.ccm.2023.08.011 | DOI Listing |
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