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Perturbation of peptidoglycan recycling by anti-folates and design of a dual-action inhibitor.
mBio
January 2025
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Unlabelled: Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and structural integrity, and is a key antibiotic target. Its synthesis and turnover are carefully coordinated with other cellular processes and pathways. Despite established connections between the biosynthesis of PG and the outer membrane, or PG and DNA replication, links between PG and folate metabolism remain comparatively unexplored.
View Article and Find Full Text PDFThe influence of familiarity between the surgeon and their assistant on patient outcomes: a prospective observational cohort study.
Int J Surg
January 2025
Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: The inverse relationship between increased surgical team familiarity and reduced operative time is established, but its effect on patient outcomes remains uncertain.
Materials And Methods: A prospective cohort study including operations by attending surgeons between 1 November 2020 and 31 December 2021 across fourteen surgical departments from four French university hospitals. Surgical team familiarity was measured as the cumulative number of previous operations performed by the same dyad of attending and assisting surgeons.
Changes in incidence and epidemiology of antimicrobial resistant pathogens before and during the COVID-19 pandemic in Germany, 2015-2022.
BMC Microbiol
January 2025
Department of Infectious Disease Epidemiology, Robert Koch Institute (RKI), Berlin, Germany.
Background: Carbapenem-resistant Gram-negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are among WHO's priority pathogens with antimicrobial resistance (AMR). Studies suggest potential impacts of the COVID-19-pandemic on AMR. We described changes in AMR incidence and epidemiology in Germany during the COVID-19-pandemic.
View Article and Find Full Text PDFAn optimal workflow scheduling in IoT-fog-cloud system for minimizing time and energy.
Sci Rep
January 2025
School of Information Engineering, Sanming University, Sanming, 365004, China.
Today, with the increasing use of the Internet of Things (IoT) in the world, various workflows that need to be stored and processed on the computing platforms. But this issue, causes an increase in costs for computing resources providers, and as a result, system Energy Consumption (EC) is also reduced. Therefore, this paper examines the workflow scheduling problem of IoT devices in the fog-cloud environment, where reducing the EC of the computing system and reducing the MakeSpan Time (MST) of workflows as main objectives, under the constraints of priority, deadline and reliability.
View Article and Find Full Text PDFUnderstanding viral non-suppression among people with HIV engaged in a mobile health program.
AIDS Care
January 2025
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
By consistently taking medication, people with HIV (PWH) can attain viral suppression, improving their health and reducing transmission risk. PositiveLinks (PL) is a clinic-deployed mobile platform designed to improve engagement in care for PWH by enabling them to track their medications, connect with peers, and communicate with providers. This project investigated the experience of PL users who had recent periods of viral non-suppression to understand how these high-risk episodes can be predicted and prevented.
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