AI Article Synopsis
- The ribosomal DNA locus (rDNA) is crucial for cell function as it encodes ribosomal RNAs, impacting both metabolism and genome stability.
- The repetitive nature of rDNA requires maintenance of sequence homogeneity through recombination, which is essential for genomic integrity.
- The review focuses on the interplay of DNA processes—like replication and transcription—in regulating rDNA and preserving stability, particularly in the model organism Saccharomyces cerevisiae.
Article Abstract
The ribosomal DNA locus (rDNA) is central for the functioning of cells because it encodes ribosomal RNAs, key components of ribosomes, and also because of its links to fundamental metabolic processes, with significant impact on genome integrity and aging. The repetitive nature of the rDNA gene units forces the locus to maintain sequence homogeneity through recombination processes that are closely related to genomic stability. The co-presence of basic DNA transactions, such as replication, transcription by major RNA polymerases, and recombination, in a defined and restricted area of the genome is of particular relevance as it affects the stability of the rDNA locus by both direct and indirect mechanisms. This condition is well exemplified by the rDNA of Saccharomyces cerevisiae. In this review we summarize essential knowledge on how the complexity and overlap of different processes contribute to the control of rDNA and genomic stability in this model organism.
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| http://dx.doi.org/10.1016/j.semcdb.2024.01.004 | DOI Listing |
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