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Mannose-specific plant and microbial lectins as antiviral agents: A review. | LitMetric

AI Article Synopsis

  • Lectins are carbohydrate-binding proteins categorized by their structure and sugar specificity, making them important for diagnostic and drug discovery purposes.
  • Recent research highlights the potential of mannose-specific lectins as effective antiviral agents against a range of viruses, including HIV, Ebola, and SARS-CoV-2.
  • The review explores the classification, structure, and antiviral mechanisms of mannose-binding lectins (MBLs) from plants and microbes, emphasizing their therapeutic applications against viral infections.

Article Abstract

Lectins are non-immunological carbohydrate-binding proteins classified on the basis of their structure, origin, and sugar specificity. The binding specificity of such proteins with the surface glycan moiety determines their activity and clinical applications. Thus, lectins hold great potential as diagnostic and drug discovery agents and as novel biopharmaceutical products. In recent years, significant advancements have been made in understanding plant and microbial lectins as therapeutic agents against various viral diseases. Among them, mannose-specific lectins have being proven as promising antiviral agents against a variety of viruses, such as HIV, Influenza, Herpes, Ebola, Hepatitis, Severe Acute Respiratory Syndrome Coronavirus-1 (SARS-CoV-1), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) and most recent Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The binding of mannose-binding lectins (MBLs) from plants and microbes to high-mannose containing N-glycans (which may be simple or complex) of glycoproteins found on the surface of viruses has been found to be highly specific and mainly responsible for their antiviral activity. MBLs target various steps in the viral life cycle, including viral attachment, entry and replication. The present review discusses the brief classification and structure of lectins along with antiviral activity of various mannose-specific lectins from plants and microbial sources and their diagnostic and therapeutic applications against viral diseases.

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Source
http://dx.doi.org/10.1007/s10719-023-10142-7DOI Listing

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