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Bridging the gap: The endocannabinoid system as a functional fulcrum for benzodiazepines in a novel frontier of anxiety pharmacotherapy.
Pharmacol Ther
January 2025
Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
While benzodiazepines have been a mainstay of the pharmacotherapy of anxiety disorders, their short-term efficacy and risk of abuse have driven the exploration of alternative treatment approaches. The endocannabinoid (eCB) system has emerged as a key modulator of anxiety-related processes, with evidence suggesting dynamic interactions between the eCB system and the GABAergic system, the primary target of benzodiazepines. According to the existing literature, the activation of the cannabinoid receptors has been shown to exert anxiolytic effects, while their blockade or genetic deletion results in heightened anxiety-like responses.
View Article and Find Full Text PDFAdvancing long-read nanopore genome assembly and accurate variant calling for rare disease detection.
Am J Hum Genet
January 2025
UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA. Electronic address:
More than 50% of families with suspected rare monogenic diseases remain unsolved after whole-genome analysis by short-read sequencing (SRS). Long-read sequencing (LRS) could help bridge this diagnostic gap by capturing variants inaccessible to SRS, facilitating long-range mapping and phasing and providing haplotype-resolved methylation profiling. To evaluate LRS's additional diagnostic yield, we sequenced a rare-disease cohort of 98 samples from 41 families, using nanopore sequencing, achieving per sample ∼36× average coverage and 32-kb read N50 from a single flow cell.
View Article and Find Full Text PDFEnsuring Medical Device Safety: The Role of Standards Organizations and Regulatory Bodies.
J Med Syst
January 2025
Advancing a Healthier Wisconsin Endowment, Medical College of Wisconsin, Milwaukee, WI, USA.
Medical devices significantly enhance healthcare by integrating advanced technology to improve patient outcomes. Ensuring their safety and reliability requires a delicate balance between innovation and rigorous oversight, managed through the collaborative efforts of standards development organizations, standards accrediting organizations, and regulatory agencies such as the U.S.
View Article and Find Full Text PDFResilience Amidst Adversity: Experiences of Black Older Adults During the COVID-19 Pandemic.
Gerontologist
January 2025
School of Social Work, McGill University, Montreal, QC, Canada.
Background And Objectives: The paucity of research and policy on the impact of COVID-19 on the experiences of Black older adults in Canada and around the world has intensified the enduring impacts of racism on their health and well-being. To bridge this gap, our study explored the mental health of Black older adults in Montreal during the early period of the pandemic.
Research Design And Methods: Using an Afro-emancipatory mixed-method research design, we collected and analyzed data from three sources: a survey, focus group interview with service providers from Black community organizations, and individual interviews with Black older adults.
Bio-inspired preparation of Ag NPs, rGO, and Ag/rGO nanocomposites for acoustical, antioxidant, and plant growth regulatory studies.
Sci Rep
January 2025
Department of Chemistry, Devchand College, Arjunnagar, Kolhapur, MH, 591237, India.
Acoustical properties are essential for understanding the molecular interactions in fluids, as they influence the physicochemical behavior of liquids and determine their suitability for diverse applications. This study investigated the acoustical parameters of silver nanoparticles (Ag NPs), reduced graphene oxide (rGO), and Ag/rGO nanocomposite nanofluids at varying concentrations. Ag NPs and Ag/rGO nanocomposites were synthesized via a Bos taurus indicus (BTI) metabolic waste-assisted method and characterized using advanced techniques, including XRD, TEM, Raman, DLS, zeta potential, and XPS.
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