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ReIU: an efficient preliminary framework for Alzheimer patients based on multi-model data.
Front Public Health
January 2025
Engineering Research Center of Photoelectric Detection and Perception Technology, Yunnan Normal University, Kunming, China.
The rising incidence of Alzheimer's disease (AD) poses significant challenges to traditional diagnostic methods, which primarily rely on neuropsychological assessments and brain MRIs. The advent of deep learning in medical diagnosis opens new possibilities for early AD detection. In this study, we introduce retinal vessel segmentation methods based on U-Net ad iterative registration Learning (ReIU), which extract retinal vessel maps from OCT angiography (OCT-A) facilities.
View Article and Find Full Text PDFClinical and Structural Parameters in Autosomal Dominant Optic Atrophy Patients: A Cross-Sectional Study Using Optical Coherence Tomography.
J Neuroophthalmol
November 2024
Ophthalmology Department (AC-C, MF-R, SA-A, RA, BS-D), Seu Maternitat, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain; Faculty of Medicine and Health Sciences (AC-C, SA-A, BS-D), Universitat de Barcelona, Barcelona, Spain; Fundació Per La Recerca Biomèdica-IDIBAPS (MF-R, SA-A, BS-D), Barcelona, Spain; and Ophthalmology Department (MS-G), Consorci Mar Parc de Salut de Barcelona, Barcelona, Spain.
Background: Autosomal Dominant Optic Atrophy (ADOA) is a hereditary optic neuropathy characterized by retinal ganglion cell degeneration and optic nerve fiber loss. This study examined the correlation between clinical and structural parameters in patients with ADOA using optical coherence tomography (OCT) and explored potential clinical biomarkers.
Methods: A cross-sectional, case-control observational study included 27 patients with ADOA and 27 age- and sex-matched healthy controls.
Compartmental analysis of retinal vascular parameters and thickness in myopic eyes using SS-OCTA.
Front Med (Lausanne)
December 2024
Chongqing Key Laboratory of Prevention and Treatment on Major Blinding Diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- The study examined how myopia affects the thickness and structure of retinal blood vessels using advanced imaging technology in 100 participants.
- The findings revealed that individuals with high myopia had significantly lower vessel density and thinner retinal layers, particularly noticeable in the superficial and nerve fiber layers.
- There was a noted correlation between certain ocular parameters, such as axial length to curvature radius ratio, and retinal thickness in non-high myopic eyes, while high myopic eyes showed less correlation in these aspects.
Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.
Theranostics
January 2025
School of Pen-Tung Sah Institute of Micro-Nano Science and Technology, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Center for Molecular Imaging and Translational Medicine, Department of Vascular & Tumor Interventional Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Brain diseases are a leading cause of disability and death worldwide. Early detection can lead to earlier intervention and better outcomes for patients. In recent years, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging have been widely used in stroke, traumatic brain injury (TBI), and brain cancer due to their advantages of , unlabeled, and high-resolution 3D microvessel imaging at the capillary resolution level.
View Article and Find Full Text PDFInflammatory choroidal neovascularization: An evidence-based update.
Surv Ophthalmol
December 2024
Ophthalmology Unit, IRCSS Ospedale San Raffaele, Via Olgettina 60, Milan 20132, Italy; School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy. Electronic address:
Inflammatory choroidal neovascularization (iCNV) significantly contributes to vision impairment and ranks as the third primary cause of CNV. Arising from both infectious and noninfectious uveitis, iCNV's pathogenesis involves Bruch membrane rupture, local inflammation, and choriocapillaris ischemia. The diagnosis of iCNV is challenging due to its symptomatic overlap with other uveitis-related conditions.
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