AI Article Synopsis
- The study investigates the relationship between ozone (O) exposure during pregnancy and the risk of preterm birth (PTB) by combining two cohorts from Henan Province.
- Cohort 1 showed that PTB risk decreased with higher O exposure, while Cohort 2 indicated an increase in PTB risk with greater exposure, indicating a nonlinear (U-shaped) relationship.
- It was found that increased telomere length was associated with a reduced risk of PTB only at moderate O exposure levels, with no significant association at extreme O concentrations.
Article Abstract
There are conflicting findings regarding the association of ozone (O) exposure with preterm birth (PTB) occurrence. In the present study, two cohorts were combined to explore the relationship between maternal O exposure during pregnancy and PTB risk, and analyze the underlying mechanisms of this relationship in terms of alterations in the preconception telomere length. Cohort 1 included mothers who participated in the National Free Preconception Health Examination Project in Henan Province from 2014 to 2018 along with their newborns (n = 1,066,696). Cohort 2 comprised mothers who conceived between 2016 and 2018 and their newborns (n = 1871) from six areas in Henan Province. The telomere length was assessed in the peripheral blood of mothers at the preconception stage. Data on air pollutant concentrations were collected from environmental monitoring stations and individual exposures were assessed using an inverse distance-weighted model. O concentrations (100.60 ± 14.13 μg/m) were lower in Cohort 1 than in Cohort 2 (114.09 ± 15.17 μg/m). Linear analyses showed that PTB risk decreased with increasing O exposure concentrations in Cohort 1 but increased with increasing O exposure concentrations in Cohort 2. Nonlinear analyses revealed that PTB risk tended to decrease and then increase with increasing O exposure concentrations in both cohorts. Besides, PTB risk was reduced by 88% for each-unit increase in telomere length in those exposed to moderate O concentrations (92.4-123.7 μg/m, P < 0.05). While no significant association was observed between telomere length and PTB at extreme O concentration exposure during entire pregnancy (<92.4 or >123.7 μg/m, P > 0.05) in Cohort 2. These findings reveal a nonlinear (U-shaped) relationship between O exposure and PTB risk. Furthermore, telomere with elevated length was associated with decreased risk of PTB only when exposed to moderate concentrations of O, but not when exposed to extreme concentrations of O during pregnancy.
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| http://dx.doi.org/10.1016/j.envpol.2024.123366 | DOI Listing |
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