Background Objectives: The goal of this study was to see how well an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) assisted healthcare personnel in selecting relevant medications for filariasis therapy. A team of medical specialists and tropical medicine experts reviewed ChatGPT's recommendations for ten hypothetical filariasis clinical situations.
Methods: The purpose of this study was to look at the effectiveness of an AI language model called Chat Generative Pre-trained Transformer (ChatGPT) in supporting healthcare providers in picking appropriate drugs for filariasis treatment. Ten hypothetical filariasis clinical cases were submitted to ChatGPT, and its recommendations were evaluated by a panel of medical professionals and tropical medicine experts.
Results: ChatGPT gave appropriate suggestions for potential medication repurposing in filariasis treatment in all ten clinical scenarios. Its drug recommendations were in line with current medical research and literature. Despite the lack of particular treatment regimens, ChatGPT's general ideas proved useful for healthcare practitioners, providing insights and updates on prospective drug repurposing tactics.
Interpretation Conclusion: ChatGPT shows promise as a useful method for repurposing drugs in the treatment of filariasis. Its thorough and brief responses make it useful for finding possible pharmacological candidates. However, it is critical to recognize ChatGPT's limitations, such as the requirement for additional clinical information and the inability to change therapy. Further research and development are required to optimize its use in filariasis therapy settings.
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http://dx.doi.org/10.4103/0972-9062.393975 | DOI Listing |
BMC Infect Dis
January 2025
Pan-African Community Initiative on Education and Health (PACIEH), Ekulu West GRA, No. 8 Somto Anugwom Close, Enugu, Enugu State, 400102, Nigeria.
Introduction: Nigeria has a significant burden of NTDs with more than 120 million people at risk of the dominant NTDs namely Lymphatic Filariasis, Onchocerciasis, and Schistosomiasis. Control efforts have involved the four levels of governance with programs focused on vector control, preventive chemotherapy, water, sanitation and health education. However, the coordination across these levels and with multiple stakeholders remains unclear especially in states like Taraba that have received significant funding from local non-governmental organisations.
View Article and Find Full Text PDFBMC Res Notes
January 2025
Helen Keller International, New York, USA.
Objective: Sierra Leone, a country where onchocerciasis is endemic in 14 of the 16 districts, was the focus of our investigation. Despite 17 rounds of annual ivermectin treatment since 2005, a report circulated by a local politician indicated an increase in cases of suspected onchocerciasis-related vision impairment in two villages (Mangobo and Petifu) in Tonkolili district. In response, the National Neglected Tropical Disease Program conducted a comprehensive investigation.
View Article and Find Full Text PDFPLoS One
January 2025
Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.
Background: Lymphatic filariasis (LF), a mosquito-borne parasitic disease caused by three species of filarial worms, was first detected in Niue, a small Pacific Island nation of approximately 1,600 people, in 1954. After extensive efforts involving multiple rounds of Mass Drug Administration, Niue was validated by the World Health Organization (WHO) as having e4liminated LF as a public health problem in 2016. However, no surveillance has been conducted since validation to confirm infection rates have remained below WHO's elimination threshold.
View Article and Find Full Text PDFParasit Vectors
January 2025
National Centre for Epidemiology and Population Health, Australian National University, 62 Mills Road, Canberra, 2601, ACT, Australia.
Background: Elimination of lymphatic filariasis (LF) is a World Health Organization goal, with several countries at or near prevalence thresholds. Where LF cases remain after mass drug administration, they tend to be spatially clustered, with an overdispersed individual worm burden. Both individual and spatial heterogeneities can cause aggregation of infection; however, few studies have investigated the drivers of heterogeneity and implications for disease elimination.
View Article and Find Full Text PDFPathogens
December 2024
School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou 310018, China.
is a parasite transmitted by mosquitoes and can cause a neglected tropical disease called Lymphatic filariasis. However, the genome of was not well studied, making novel drug development difficult. This study aims to identify microRNA, annotate protein function, and explore the pathogenic mechanism of by genome-wide analysis.
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