This paper is the result of a scale validation process, applicable to social science research, which allows the constructs of otherness and coexistence and their relationship to be trasnformed into measurable, systematized variables. In turn, this scale is the product of a research project whose main objectives were (i) to demonstrate the relationship between coexistence as an independent variable and otherness as a dependent variable, and (ii) to create and statistically validate a scale to measure both variables, so to use it in applied research. The sample consisted of 600 participants. Three instruments were used: two semantic differentials and a 33-item questionnaire. The application was carried out virtually due to the SARS-CoV-2 virus. The method includes a mixed type of work, i.e., qualitative, and quantitative procedures. The results showed two factors, the other as strange or foreign and the other as equal. The final scale consisted of 10 items, with a Cronbach's alpha of 0.86 and variance explaining 58% of the otherness.
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http://dx.doi.org/10.1186/s40359-023-01505-8 | DOI Listing |
Curr Opin Genet Dev
January 2025
Department of Biochemistry and Molecular Biophysics, Program for Mathematical Genomics, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:
Enhancers in metazoan genomes are known to activate their target genes across both short and long genomic distances. Recent advances in chromosome conformation capture assays and single-cell imaging have shed light on the underlying chromatin contacts and dynamics. Yet the relationship between 3D physical enhancer-promoter (E-P) interactions and transcriptional activation remains unresolved.
View Article and Find Full Text PDFBlood
January 2025
Fred Hutchinson Cancer Center, Seattle, Washington, United States.
Sclerosis is a highly morbid manifestation of chronic GVHD (cGVHD), associated with distressing symptoms and significant long-term disability. A patient-reported outcome measure (PRO) for cGVHD-associated sclerosis is essential to advance therapeutic trials. We aimed to develop a PRO for adults with cGVHD-associated sclerosis and evaluate and refine its content validity.
View Article and Find Full Text PDFJ Med Internet Res
January 2025
Graduate School of Health Science and Technology, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Background: Artificial intelligence (AI) social chatbots represent a major advancement in merging technology with mental health, offering benefits through natural and emotional communication. Unlike task-oriented chatbots, social chatbots build relationships and provide social support, which can positively impact mental health outcomes like loneliness and social anxiety. However, the specific effects and mechanisms through which these chatbots influence mental health remain underexplored.
View Article and Find Full Text PDFJ Trauma Nurs
January 2025
Author Affiliations: School of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai (Mss Jiang and Ying and Drs Xu, Cao, and Zhou); and Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China (Ms Liu).
Background: The psychological resilience of patients with traumatic lower extremity fractures is relevant and has been studied in the postoperative rehabilitation phase; yet, few studies have focused on the early preoperative phase.
Objective: This study aims to explore preoperative psychological resilience in patients with traumatic lower extremity fractures.
Methods: This single-center cross-sectional survey design study was conducted over 5 months from December 2022 to April 2023 in a tertiary hospital in Shanghai, China.
JCO Clin Cancer Inform
January 2025
SimBioSys Inc, Chicago, IL.
Purpose: Perfusion modeling presents significant opportunities for imaging biomarker development in breast cancer but has historically been held back by the need for data beyond the clinical standard of care (SoC) and uncertainty in the interpretability of results. We aimed to design a perfusion model applicable to breast cancer SoC dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) series with results stable to low temporal resolution imaging, comparable with published results using full-resolution DCE-MRI, and correlative with orthogonal imaging modalities indicative of biophysical markers.
Methods: Subsampled high-temporal-resolution DCE-MRI series were run through our perfusion model and resulting fits were compared for consistency.
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