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The importance of animal specificity in animal experimentation, part II: Physiological challenges and opportunities in relation to pediatric urology. | LitMetric

The importance of animal specificity in animal experimentation, part II: Physiological challenges and opportunities in relation to pediatric urology.

J Pediatr Urol

Department of Pediatric Surgery, Surgical Clinic C, Rigshospitalet, Copenhagen University, Clinical Medicine, Copenhagen, Denmark; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Published: April 2024

AI Article Synopsis

  • Animal experimentation in Pediatric Urology requires understanding physiological differences between species and selecting appropriate disease models instead of just healthy animals.
  • Diseased models can better simulate human pathologies, especially for conditions like congenital malformations and effects of prenatal factors.
  • Properly formulating research questions is essential before choosing the right animal models and species for these studies.

Article Abstract

When performing animal experimentation in Pediatric Urology studies, it is important to be aware of physiological differences between species and to understand when relevant disease models are available. Diseased animal models may be more relevant in many cases, rather than performing studies in healthy and normally developed animals. For example, they may be more appropriate for the study of congenital malformations, to investigate the secondary effects of prenatal urinary obstruction, to study the effect of prenatal exposure to endogenous or exogenous factors which may lead to disease, or in testing bioengineered structures. In this short educational article, we aim to describe some disease models that have been used to simulate human pathologies and how, if properly designed, these studies can lead to important new knowledge for human translation. In addition, we also highlight the importance of formulating a research question(s) before deciding on the animal experimental model and species to choose.

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Source
http://dx.doi.org/10.1016/j.jpurol.2023.12.010DOI Listing

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