AI Article Synopsis
- Inflammation is key in coronary artery disease (CAD), and anti-inflammatory drugs like colchicine show promise in reducing related ischemic events.
- Colchicine, a long-used anti-inflammatory medication, may help limit atherosclerosis progression in CAD patients by targeting specific immune cell activities.
- Recent studies suggest low doses of colchicine can lower the risk of serious complications in CAD, including repeat surgeries, heart attacks, and strokes, prompting a review of its benefits and potential side effects.
Article Abstract
Inflammation plays a central role in coronary artery disease (CAD), and recent data have shown that anti-inflammatory drugs have the potential to reduce ischemic events in CAD patients. Colchicine is an ancient anti-inflammatory drug that targets neutrophil and inflammasome activities. It has been prescribed for decades for different rheumatological conditions. Given the important role of inflammation in the development of cardiovascular disease, there has been considerable interest in studying colchicine's potential to limit the progression of atherosclerosis among afflicted patients. In fact, there is a growing body of randomized data suggesting that use of low-dose colchicine reduces the risk of ischemic events in patients with CAD, particularly repeated revascularizations, new myocardial infarctions and strokes. This review article summarizes background information-including possible side effects and contraindications-as well as the current evidence backing up the use of colchicine in patients with established CAD.
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| http://dx.doi.org/10.1016/j.ejim.2024.01.004 | DOI Listing |
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