AI Article Synopsis
- * Our findings showed a clear dose-response link where longer LTL and gTL were associated with an increased risk of lung cancer, especially adenocarcinoma, with strong associations noted among those who have never smoked.
- * Mendelian Randomization analyses indicated a causal relationship, suggesting that longer telomere length significantly raises lung cancer risk (HR=1.87), particularly for adenocarcinoma (HR=2.45).
Article Abstract
We investigated phenotypic leucocyte telomere length (LTL), genetically predicted LTL (gTL), and lung cancer risk among 371 890 participants, including 2829 incident cases, from the UK Biobank. Using multivariable Cox regression, we found dose-response relationships between longer phenotypic LTL (p-trend=2.6×10), longer gTL predicted using a polygenic score with 130 genetic instruments (p-trend=4.2×10), and overall lung cancer risk, particularly for adenocarcinoma. The associations were prominent among never smokers. Mendelian Randomization analyses supported causal associations between longer telomere length and lung cancer (HR=1.87, 95% CI: 1.49 to 2.36, p=4.0×10), particularly adenocarcinoma (HR=2.45, 95%CI: 1.69 to 3.57, p=6.5×10).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923134 | PMC |
| http://dx.doi.org/10.1136/thorax-2023-220076 | DOI Listing |
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