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We present both experimental and simulation results for a fully etched, C-band GC fabricated in an 800 nm silicon nitride platform that significantly reduces backreflections. They are minimized by truncating the initial grates, which deflect reflected light at an oblique angle and excite higher-order modes in the tapered waveguide that is filtered out. Insertion losses resulting from this modification of the grating coupler are mitigated by an adaptive redesign of the grates that corrects incurred errors in the generated phase front.
View Article and Find Full Text PDFBisphosphonate-mineralized nano-IFNγ suppresses residual tumor growth caused by incomplete radiofrequency ablation through metabolically remodeling tumor-associated macrophages.
Theranostics
January 2025
Beijing Key Laboratory of Molecular Pharmaceutics and Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Radiofrequency ablation (RFA), as a minimally invasive surgery strategy based on local thermal-killing effect, is widely used in the clinical treatment of multiple solid tumors. Nevertheless, RFA cannot achieve the complete elimination of tumor lesions with larger burden or proximity to blood vessels. Incomplete RFA (iRFA) has even been validated to promote residual tumor growth due to the suppressive tumor immune microenvironment (TIME).
View Article and Find Full Text PDFAscorbate-loaded MgFe layered double hydroxide for osteomyelitis treatment.
J Control Release
January 2025
Department of Traumatology and Orthopaedic Surgery, Huizhou Central People's Hospital, Huizhou 516001, China; Hui Zhou-Hong Kong Bone Health Joint Research Center, Institute of Orthopaedics, Huizhou Central People's Hospital, Huizhou 516001, China. Electronic address:
Article Synopsis
- Bacterial infections pose major challenges in orthopedic treatments, as traditional antibiotics can damage cells and lead to resistance.
- A new nanoenzyme-mimicking drug, AA@LDH, has been developed that combines magnesium iron layered double hydroxide with ascorbic acid, effectively generating reactive oxygen species to kill bacteria like S. aureus and E. coli.
- This system not only significantly reduces bacterial presence but also promotes bone healing by enhancing cell function and supporting tissue regeneration, representing a promising advancement in medical treatments.
Scalable Reshaping of Diamond Particles via Programmable Nanosculpting.
ACS Nano
December 2024
Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong 999077, China.
Diamond particles have many interesting properties and possible applications. However, producing diamond particles with well-defined shapes on a large scale is challenging because diamonds are chemically inert and extremely hard. Here, we show that air oxidation, a routine method for purifying diamonds, can be used to precisely shape diamond particles at scale.
View Article and Find Full Text PDFObjective: This case report describes a multidisciplinary approach using a digital wax-up to fabricate a gingivectomy and crown lengthening guides, to reshape a lateral incisor into a central incisor and improve overall esthetics.
Clinical Considerations: Comprehensive treatment planning is crucial when executing a multidisciplinary workflow, with digital tools proving to be invaluable aids. In the present case, a digitally designed wax-up was employed to generate a digital surgical guide for reshaping the gingival architecture of a lateral incisor into that of a central incisor, followed by composite restorations.
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