AI Article Synopsis
- Dioxins and furans (PCDD/Fs) are long-lasting pollutants that accumulate in the environment and can negatively impact fetal growth during pregnancy, as they can transfer to the fetus and newborns through breastfeeding.
- The study examined PCDD/Fs in breast milk and cord serum from pregnant women, finding high detection rates in both (70.7% in breast milk and 46.9-55.1% in cord serum) with significant correlations between them.
- Additionally, the research highlighted various factors influencing PCDD/F levels, indicating associations with maternal diet, age, and lifestyle factors like smoking and weight before pregnancy.
Article Abstract
Dioxins and furans (PCDD/Fs) are anthropogenic pollutants that persist in the environment for long years, bioaccumulating in food & contaminating humans. In pregnancy, they can transfer through the placenta and reach the fetus, which negatively affects fetal growth. They can also reach newborns through breastfeeding. In this study, we focused on this critical subpopulation and identified the presence of PCDD/Fs among pregnant women in breast milk (n = 41) and cord serum (n = 49); we assessed the correlation between different matrices, evaluated the predictors and associations with newborn anthropometric measurements. Over 70.7 % of PCDD/Fs were detected in breast milk and 46.9-55.1 % in cord serum. Cord/maternal serum and breast milk to maternal serum ratios were > 1 with a significant positive Spearman correlation (0.669-0.729). Breast milk & maternal serum PCDD/Fs were associated inversely with age and positively with red meat intake. Cord serum PCDD/Fs were inversely associated with pre-pregnancy weight loss and passive smoking. Parity and gestational weight gain showed positive associations with Z-scores at birth. Z-score differences showed negative and positive associations with passive smoking and pre-pregnancy BMI respectively.
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| http://dx.doi.org/10.1016/j.marpolbul.2024.116032 | DOI Listing |
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