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Unleashing the Power of Covalent Drugs for Protein Degradation.
Med Res Rev
January 2025
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Targeted protein degradation (TPD) has emerged as a significant therapeutic approach for a variety of diseases, including cancer. Advances in TPD techniques, such as molecular glue (MG) and lysosome-dependent strategies, have shown substantial progress since the inception of the first PROTAC in 2001. The PROTAC methodology represents the forefront of TPD technology, with ongoing evaluation in more than 20 clinical trials for the treatment of diverse medical conditions.
View Article and Find Full Text PDFUnleashing the potential of Er-Tm coupling for the regulation of power-dependent multi-color upconversion luminescence.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Huzhou Key Laboratory of Materials for Energy Conversion and Storage, College of Science, Huzhou University, Huzhou 313000, China. Electronic address:
1550 nm-responsive upconversion luminescence (UCL) has attracted increasing attention due to its potential applicability in a new generation of bio-probes and photonic devices. However, regulating multi-color UCL with pump power remains a challenge. In this work, through constructing the coupling between Er and Tm ions and suppressing the energy transfer upconversion process of Er ions, the response of UCL color in Gd(MoO):Er/Tm to pump power is enhanced significantly.
View Article and Find Full Text PDFThe Potential of Natural Products in Metabolic Disease Management: A Thorough Exploration of the Case of Uganda.
Endocr Metab Immune Disord Drug Targets
January 2025
Research and Development Cell, and Parul Institute of Applied Sciences, Parul University, P.O. Limda, Ta.Waghodia, Dist. Vadodara, Gujarat-391760; India.
As Ugandans grapple with an increase in metabolic diseases, researchers are turning to their rich tradition of natural remedies. This review explores promising plants, such as Moringa oleifera, bridging the gap between the wisdom of Ugandan healers and modern science. Although these plants show potential, challenges remain.
View Article and Find Full Text PDFMaximizing Graft Diameter: Unleashing the Power of Triple-fold Hamstring Autografts for Anterior Cruciate Ligament Reconstruction.
Arthrosc Tech
December 2024
Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.
In this article, we explain a simple method to effectively enhance the graft size and maintain the tissue integrity of a hamstring autograft. The triple-fold technique is useful for creating a soft-tissue size and length suitable for anterior cruciate ligament reconstruction.
View Article and Find Full Text PDFUnleashing the Power of immune Checkpoints: A new strategy for enhancing Treg cells depletion to boost antitumor immunity.
Int Immunopharmacol
January 2025
Department of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China; Key Laboratory of Tooth Development and Bone Remodeling of Jilin Province, School and Hospital of Stomatology, Jilin University, Changchun, China. Electronic address:
Article Synopsis
- Regulatory T (Treg) cells are a type of immunosuppressive CD4 T cells that can hinder anti-tumor immune responses, creating challenges in cancer treatment.
- Various immune checkpoints (like PD-1/PD-L1, CTLA-4) play critical roles in managing Treg cell activity and proliferation in tumors, impacting overall tumor immunity.
- Targeting these checkpoints and combining therapies, such as immune checkpoint blockade and CCR8-targeted treatments, may enhance anti-tumor immunity and improve results for cancer patients.
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