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Inflammation-induced Generation of Splenic Erythroblast-like Ter- Cells Inhibits the Progression of Acute Lung Injury via Artemin.
Am J Respir Cell Mol Biol
January 2025
Second Military Medical University First Hospital, Department of Respiratory and Critical Care Medicine, Shanghai, China;
Identifying inflammation-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding the progession of ALI/ARDS. Nevertheless, how primary inflammation-induced non-leukocyte populations in distal organs contribute to ALI/ARDS remains poorly defined. Here, we report one population of erythroblast-like cells (Ter-cells) deriving from megakaryocyte- erythroid progenitor cells with a unique Ter-119+CD45-CD71+ phenotype in ALI/ARDS.
View Article and Find Full Text PDFThe lung is a megakaryocyte outpost that can defend against thrombocytopenic attack.
J Clin Invest
November 2024
Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, Massachusetts, USA.
Lung megakaryocytes (Mks) are a unique subset of Mks that are distinct from their bone marrow counterparts. Recent evidence suggests that lung Mks favor an immune phenotype, but have unclear contributions to the total platelet mass. In this issue of the JCI, Livada et al.
View Article and Find Full Text PDFTriple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report.
J Med Case Rep
October 2024
Department of Diagnostic Pathology, Tokyo Women's Medical University Adachi Medical Center, 4-33-1, Kohoku, Adachi-ku, 123-8558, Tokyo, Japan.
Article Synopsis
- Segregated-nucleus-containing atypical monocytes have been identified in mice and are believed to induce fibrosis in drug-injured lungs, with a human counterpart potentially existing in primary myelofibrosis.
- A 74-year-old male patient with primary myelofibrosis had anemia and elevated lactate dehydrogenase, and his bone marrow showed histological features consistent with the disease.
- Immunohistochemical analysis revealed the presence of some CD16MSR1CEACAM1 cells in the patient's bone marrow, suggesting a possible connection to murine atypical monocyte characteristics.
Article Synopsis
- Platelets inherit RNA from their parent megakaryocytes and this study uses single-cell RNA sequencing to investigate the platelet transcriptome, which has not been thoroughly explored before.
- Findings revealed significant variability in gene expression among platelets, with common markers showing lower than expected abundance and highlighting that current identification methods often misclassify platelets.
- The research stresses the importance of specialized sequencing techniques for accurate platelet profiling, which could lead to advancements in understanding platelet biology and their potential use in immune therapy and as biomarkers for diseases like cancer.
The role of platelets and megakaryocytes in sepsis and ARDS.
J Physiol
November 2024
Division of Pulmonary, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Since the global COVID-19 pandemic, there has been a renewed focus on lung injury during infection. Systemic inflammatory responses such as acute respiratory distress syndrome (ARDS) and sepsis are a leading cause of morbidity and mortality for both adults and children. Improvements in clinical care have improved outcomes but mortality remains ∼40% and significant morbidity persists for those patients with severe disease.
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