EFFECTS OF MATERNAL BLOOD LEAD IN THE PRENATAL PERIOD ON NEWBORNS AND THE SPECIFICS OF THE CONDITION AT BIRTH.

The study aimed to study the aspects of the impact of lead in newborns in the perinatal period.Clusters of 354 pregnant women and newborns were studied. Determination of the lead index in the venous blood of pregnant women was carried out and their results were analyzed at birth. Lead was determined in the mother's blood using the atomic-absorption spectrophotometry method. Blood was taken for analysis in the third trimester of pregnancy. Ordinal multinomial logistic regression (ordinal multinomial logistic regression) was used to reveal the causal relationship between the logarithm of lead content in the mother's blood (Log10(Pb)) and Apgar scores of the newborn during pregnancy and to assess its credibility. Different methods of parametric and non-parametric statistics. Statistical software package - SPSS12 was used for data processing and visualization of results.It was revealed that the deterioration of the Apgar score is observed with a high degree of certainty in newborns of 37 weeks of gestational age and less. Gender specificity of sensitivity to lead exposure has been revealed - it has been established that female newborns are more sensitive than male newborns. Which was manifested by worsening Apgar score in the first minute of life. Based on the mentioned study, it is necessary to strengthen the antenatal surveillance of pregnant women in endemic areas to detect the risks of low Apgar scores. Also, we recommend the screening of high-risk individuals for blood lead content before planning a pregnancy. Further determination of lead index should be done immediately after diagnosis of pregnancy, blood lead monitoring should be done according to local guideline. Since the specificity of the effects of lead in the mother's blood is known, the clinician is able to predict the risks in relation to the sex of the newborn at birth and to find the appropriate help in the maternity unit at the moment of birth.