AI Article Synopsis
- Primary angle-closure glaucoma (PACG) is a major cause of irreversible blindness globally, primarily caused by pupil block and secondary iris synechia.
- The study aimed to identify protein differences in the aqueous humour from patients with acute primary angle closure (APAC) compared to those with cataract only, using advanced proteomic techniques.
- Researchers identified over 400 proteins in both groups, finding 91 differentially expressed proteins, including downregulated levels of matrilin2 and transforming growth factor-β2 in the APAC group, which are linked to inflammation and tissue formation processes relevant to angle closure.
Article Abstract
Primary angle-closure glaucoma (PACG) is the leading cause of irreversible blindness in the world. Angle closure induced by pupil block and secondary iris synechia is the fundamental pathology of the PACG. The molecular mechanisms of angle closure have not yet been clearly illustrated. This study was designed to investigate the protein difference in the aqueous humour and explore new biomarker of the PACG. Aqueous humour (AH) was collected from patients with acute primary angle closure (APAC) and cataract (n = 10 in APAC group) and patients with cataract only (n = 10 in control group). Samples were pooled and measured using label-free proteome technology. Then, the differentially expressed proteins (DEPs) were verified by ELISA using independent AH samples (n = 20 each group). More than 400 proteins were revealed in both groups through proteomics. Comparing the two groups, there were 91DEPs. These proteins participate in biological activities such as inflammation, fibrosis, nerve growth and degeneration and metabolism. We found that the expression of transforming growth factor-β2 and matrilin2 was downregulated in the APAC group. The two proteins are related to inflammation and extracellular matrix formation, which might be involved in angle closure. This study characterized DEPs in AH of the APAC and found a downregulated protein matrilin2.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10844682 | PMC |
| http://dx.doi.org/10.1111/jcmm.18111 | DOI Listing |
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