The aim of this work was to study the possibility to use Sepitrap as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancement of poorly watersoluble drugs. Sepitrap is a microencapsulated powder solubilizer designed to simplify the manufacture of drugs in oral solid forms, not yet tested for this purpose. The performance of Sepitrap was evaluated in HME processing for amorphous solid dispersions of poorly-water soluble drugs with indomethacin as a model drug. The study was conducted using a twin-screw extruder, two compositions of Sepitrap and different loads of indomethacin, demonstrating that Sepitrap could represent a new range of carriers for amorphous solid dispersions for HME processing, reducing necessary downstream steps such as grinding.
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| http://dx.doi.org/10.1080/10837450.2024.2306802 | DOI Listing |
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