AI Article Synopsis
- C-reactive protein (CRP) is a standard test in clinical settings, while cytokine testing, like IL-6, IL-1β, and TNF-α, is primarily used for research purposes.
- A study analyzed 307 samples and found a strong correlation between CRP levels and IL-6, but no correlation with IL-1β and TNF-α.
- Patients with bacterial infections showed elevated levels of both CRP and IL-6, while CRP was notably high in those with inflammatory and autoimmune diseases, suggesting that CRP could serve as a practical indicator of IL-6 levels in diagnostics.
Article Abstract
C-reactive protein (CRP) is commonly performed, whereas cytokine testing is limited to research. To determine CRP correlation to cytokines IL-6, IL-1β and TNF-α. Consecutive samples (n = 307) were collected over 24 h. Ninety-six patients (31%) had acute infections, and 23 patients (7.5%) had autoimmune or inflammatory disease presentations. A strong correlation between CRP and two IL-6 assays (r = 0.74 and r = 0.71; p < 0.001) was present. CRP did not correlate with IL-1β and TNF-α across the data set. Bacterial infection had a significantly higher CRP and IL-6 (p < 0.001), while only CRP was elevated in inflammatory and autoimmune diseases (p < 0.001). CRP may be used as a surrogate marker of IL-6 levels in the routine diagnostic laboratories.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/bmm-2023-0708 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!