Background/objective/methods: Glutathione-S-transferase Mu1 () and glutathione peroxidase 1 () are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking. This study explored the correlation between and levels between a group of smokers with the and genes in the Saudi population and a control group and investigated the genetic risk factors in the group of smokers.
Results: The control and smokers' group ( = 50; aged 22.3 ± 3.1 years; BMI 24.6 ± 5.9 kg/m) were genotyped using quantitative polymerase chain reaction (qPCR). In comparison with the control group, the smokers' group displayed a different genotype disruption of and . Carriers of the homozygous (TT) genotype of had more than a twofold (OR = 2.71, 95% CI = 0.10-70.79, = 1.000) smoking risk than the carriers of the heterozygous (CT) genotype. Those with the gene showed no risk in the control and smokers' groups. Smokers with the TT/GG combination (homozygous for and normal for ) were identified as high risk (OR = 2.58, 95% CI = 0.096-69.341).
Conclusion: The main outcomes showed no significant association between genetic polymorphism of the and genes and cigarette smoking in the Saudi Arabian population. However, the results showed a slight decrease in the number of and gene modifications among smokers.
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| http://dx.doi.org/10.4103/jpbs.jpbs_365_23 | DOI Listing |
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