AI Article Synopsis
- Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy that can negatively affect both the mother and the baby due to complications that may arise during this period.
- * The condition involves complex mechanisms, including insulin resistance and β-cell dysfunction, with metabolic reprogramming playing a key role in maintaining metabolic balance.
- * Limited research exists on how metabolic reprogramming is linked to GDM, hence the need for reviews to explore this relationship for developing new treatment strategies to improve maternal health and lower the risk of GDM.
Article Abstract
Gestational diabetes mellitus is a prevalent metabolic disease that can impact the normal course of pregnancy and delivery, leading to adverse outcomes for both mother and child. Its pathogenesis is complex and involves various factors, such as insulin resistance and β-cell dysfunction. Metabolic reprogramming, which involves mitochondrial oxidative phosphorylation and glycolysis, is crucial for maintaining human metabolic balance and is involved in the pathogenesis and progression of gestational diabetes mellitus. However, research on the link and metabolic pathways between metabolic reprogramming and gestational diabetes mellitus is limited. Therefore, we reviewed the relationship between metabolic reprogramming and gestational diabetes mellitus to provide new therapeutic strategies for maternal health during pregnancy and reduce the risk of developing gestational diabetes mellitus.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791831 | PMC |
| http://dx.doi.org/10.3389/fendo.2023.1284160 | DOI Listing |
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