AI Article Synopsis
- Aconite, derived from the seed root of Aconitum carmichaelii, is a traditional Chinese medicine known for its benefits in restoring energy and relieving pain, but can also cause poisoning.
- The study involved administering three processed forms of aconite to 42 rats and analyzing the effects on their metabolite changes through advanced mass spectrometry.
- This research is pioneering in evaluating how different processed aconite products impact rat metabolites using a method known as pseudotargeted metabolomics.
Article Abstract
Aconite is the processed product of the seed root of Aconitum carmichaelii Debx. Aconite is a commonly used traditional Chinese medicine, which is generally used after processing. Black aconite, light aconite, and salted aconite are three different processed aconite products. They have the effects of restoring yang and saving energy enemy, dispersing cold, and relieving pain. However, clinical aconite poisoning cases have frequently been reported. In our study, we investigated the effects of three different processed aconite products on the changes of metabolites in vivo. A total of 42 rats were randomly divided into seven groups with six rats in each group. After three consecutive days of intragastric administration of 2.7 g/kg of the aconite-processed product, rat serums were obtained. The rat metabolites were detected using liquid chromatography-tandem mass spectrometry. The altered metabolites related to aconite-processed products were discovered by statistical analysis using metaboanalyst software. Our study is the first time to comprehensively evaluate the effects of three different processed aconite products on rat metabolites based on pseudotargeted metabolomics.
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| http://dx.doi.org/10.1002/jssc.202300583 | DOI Listing |
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