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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Laboratory of Neurobiology, Department of Neurology, Poznan, Poland.
Background: Alzheimer's disease (AD) is characterized by an acquired, progressive impairment of cognitive functions. The pathogenesis of this disease remains unknown. It is explained based on the following theories: amyloid cascade, inflammation, vascular, and infection hypothesis.
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Alzheimers Dement
December 2024
Institute for Regenerative Medicine, Department of Cell Biology and Genetics, School of Medicine, Texas A&M University Health Science Center, College Station, Texas, USA., College Station, TX, USA.
Background: Current treatments for Alzheimer's disease (AD) lack disease-modifying interventions. Hence, novel therapies capable of restraining AD progression and maintaining better brain function for extended periods after the initial diagnosis have great significance. Extracellular vesicles (EVs) from human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) are attractive in this context due to their robust antiinflammatory properties.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Background: Multiple AD risk genes are implicated in lipid metabolism, and plasma and brain lipid levels are altered in AD. Astrocytes are enriched in key lipid-related factors and are likely contributors to altered lipid homeostasis in AD. We hypothesize that APP/Aβ-related pathology and neuroimmune factors modulate astrocytic gene transcription that promote maladaptive changes in lipid pathways, including aberrant astrocytic production and release of lipids that could affect Aβ pathology and neuronal deficits.
View Article and Find Full Text PDFPredictors of Academic Performance Trajectories Across Early and Middle Adolescence: Links with Internalizing and Externalizing Problems.
J Youth Adolesc
January 2025
School of Population and Health, Renmin University of China, Beijing, China.
Although there is ample evidence linking academic and behavioral domains, few studies have examined the long-term, varied impacts of academic performance trajectories on problem behavior outcomes, particularly in early and middle adolescence. This study examined the different three-year academic performance trajectories, their links with behavioral outcomes, and the demographic and educational predictors that distinguish these patterns. The sample consisted of 10,279 Chinese adolescents (46.
View Article and Find Full Text PDFPeroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma.
Sci Rep
January 2025
Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, West 5th Road, Xi'an, Shaanxi, China.
Peroxiredoxin 6 (PRDX6) is one of the Peroxiredoxin family members with only 1-Cys, using glutathione as the electron donor to reduce peroxides in cells. PRDX6 has been frequently studied and its expression was associated with poor prognosis in many tumors. However, the expression of PRDX6 in multiple myeloma (MM) and its relevance with MM remain unclear.
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