Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links.

Cell Rep Med

Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, South Korea; Center for RNA Research, Institute for Basic Science, Seoul 08826, South Korea. Electronic address:

Published: January 2024

In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD dependencies for survival. Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10829863PMC
http://dx.doi.org/10.1016/j.xcrm.2023.101385DOI Listing

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